Back to search results Previous job Next job Apply Now Save job

JOB DESCRIPTION

The Position The Opportunity SE7 As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.

Key Responsibilities:

Method Development:

Design and apply LC-HRMS and

LC-MS/MS

methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.

Experimental Execution:

Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.

Data & AI Workflows:

Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.

Quality & Insight:

Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.

Cross-Functional Collaboration:

Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research. Who You Are You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.

Qualifications & Experience:

Education & Industry Experience:

PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3-5 years of direct experience in the biotechnology or pharmaceutical industry.

Bioanalytical Expertise:

Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.

Technical Mastery:

Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.

Metabolic & Computational Insight:

Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.

Collaboration & Communication:

Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $143,200

• $265,900.

Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .

JOB FACTS

Job Sub Category Research Biology Schedule Full time Job Type Regular Posted Date Jul 31st 2026 Job

ID 202607-119864

Apply Now Save job Profile recommendations See more Show less See next See even more No recommendations found Similar Jobs Postdoctoral Fellow

• Analytical Development & Quality Control, Bouvarel & Camperi Labs Location South San Francisco, California, United States of America Available in 2 categories Save Postdoctoral Fellow
• Analytical Development & Quality Control, Bouvarel & Camperi Labs 202606-113861 Postdoctoral Fellow
• Discovery Oncology, Foster Lab Location South San Francisco, California, United States of America Available in 2 categories Save Postdoctoral Fellow
• Discovery Oncology, Foster Lab 202605-113480 Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry Location South San Francisco, California, United States of America Category Research & Development Save Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry 202607-119351 Principal Scientist, Lab Head, Immunology, Cell Therapy Location South San Francisco, California, United States of America Category Research & Development Save Principal Scientist, Lab Head, Immunology, Cell Therapy 202607-119364 Senior Machine Learning Scientist, AI for Biology & Translation (AIBT) Location South San Francisco, California, United States of America Available in 2 categories Save Senior Machine Learning Scientist, AI for Biology & Translation (AIBT) 202607-119719 Senior Principal Machine Learning Scientist, AI Biology & Translation (AIBT) Location South San Francisco, California, United States of America Available in 2 categories Save Senior Principal Machine Learning Scientist, AI Biology & Translation (AIBT) 202606-114453 Senior/Principal Scientist•Synthetic Molecule Analytical Chemistry, Genentech Research and Early Development Location South San Francisco, California, United States of America Available in 3 categories Save Senior/Principal Scientist•Synthetic Molecule Analytical Chemistry, Genentech Research and Early Development 202603-107743 Scientist 3, Functional Immunogenomics Location South San Francisco, California, United States of America Category Research & Development Save Scientist 3, Functional Immunogenomics 202607-119495 Postdoctoral Fellow•Human Genetics, Bhangale Lab Location South San Francisco, California, United States of America Available in 2 categories Save Postdoctoral Fellow•Human Genetics, Bhangale Lab 202606-115492 See more See less See next See even more No recommendations found Get notified for similar jobs Sign up to receive job alerts Email• I hereby consent to the processing of my personal data for the purpose of receiving job alerts as outlined in the Privacy Notice.

To withdraw your consent to receive job alerts with effect for the future, you may for example use the unsubscribe link provided in each job alert email. Please note that your email address will be deleted immediately for that purpose. Any participation in the talent community or in the job application process will remain unaffected.

• By proceeding, I understand that my personal data will be processed in accordance with the Company Data Privacy Policy.

Submit Success! Successfully subscribed for similar jobs ok Failure! You have already subscribed for this job ok Failure! Failed to subscribed for similar jobs ok Manage alerts Success! Successfully subscribed for similar jobs Ok Failure! Ok Jobseekers Also Viewed See more See less See next See even more No recommendations found

SHARE THIS OPPORTUNITY

Share via LinkedIn Share via Facebook Share via twitter Share via email Share job link To your colleagues or friends Cancel Copy Link

LOOKING FOR A CONTRACT JOB?

Browse contract jobs via an external website hosted by Magnit Browse contract jobs Close the popup Loading... Disable Audio Description Enable Audio Description Transcript Who we are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We celebrate our unique history as the pioneers of scientific breakthroughs that have an incredible track record of improving lives. And yet, our ambitions are bigger and bolder. We are growing a team committed to the bold quest to solve the world's most complex health challenges. Joining Genentech means embracing a shared identity as a changemaker. Become A Part Of Our Success 14.7 BILLION invested in R D (2023) 40+ FDA-approved medicines for serious and life-threatening disease 24 YEARS on Fortune 100 Best Companies to Work For List

NOT READY TO APPLY?

Join our talent network and we will notify you when the right opportunity arrives. Join Community ​​​​​​​