Scientist/Senior Scientist, Biology (In Vitro Biology Lead) Kidney Experience

Scientist/Senior Scientist, Biology (In Vitro Biology Lead) Kidney Experience Employer Raptor Medicines Inc. Location Boston MA area Salary Salary commensurate with experience, fully paid medical benefits and equity Start date May 15, 2026 View more categories View less categories Discipline Science/R D , Biology , Cell Biology , Immunology , Laboratory , Molecular Biology , Pharmacokinetics Required Education Doctorate/PHD/MD Position Type Full time Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details About the Role We are seeking a highly motivated, hands-on, and scientifically rigorous Scientist/Senior Scientist with deep expertise in both in vitro and in vivo kidney biology, renal disease mechanisms, and translationally relevant kidney disease models to build and lead our kidney biology engine at a venture-backed startup biotech company. This individual will play a foundational role in establishing integrated in vitro and in vivo kidney research platforms that enable target discovery, mechanistic validation, therapeutic screening, and development candidate nomination for next-generation targeted genetic medicines. Our therapeutic focus is on kidney diseases leveraging our novel ligand-guided siRNA delivery platform. The ideal candidate combines extensive bench expertise in renal cellular biology, kidney disease models, in vivo pharmacology/efficacy studies, and translational assay development, with a strong builder mentality suited for a fast-paced, venture-backed startup. This is an unique opportunity to shape core scientific capabilities, work closely with executive leadership, and directly impact therapeutic programs from target discovery through preclinical development. This position is primarily on-site in Boston, MA. Key Responsibilities Kidney Biology Engine Development (Primary Focus) Build and lead the internal kidney biology platform spanning both in vitro and in vivo capabilities to support discovery and development of renal-targeted therapeutics Establish, optimize, and scale kidney disease-relevant cellular, molecular, and animal models Develop robust, scalable bioassays and experimental workflows to support: Kidney target biology validation Receptor expression, trafficking, and internalization characterization Ligand discovery and screening Ligand-siRNA conjugate uptake, endosomal escape, and functional knockdown In vivo PK/PD, biodistribution, efficacy, and biomarker analyses Design mechanistic assays and translational studies for kidney disease pathways relevant to therapeutic targets Program Execution Design, execute, troubleshoot, and interpret complex in vitro, ex vivo, and in vivo studies across multiple kidney disease programs Generate high-quality data packages to support discovery decisions, target prioritization, and development candidate nomination Drive scientific rigor in assay reproducibility, translational relevance, and platform scalability In Vivo Biology and Translational Leadership Lead or significantly contribute to in vivo kidney disease studies, including efficacy, biodistribution, PK/PD, and mechanistic studies Support selection, management, and interpretation of external CRO or academic in vivo studies Integrate in vitro and in vivo findings to refine therapeutic hypotheses, delivery strategies, and biomarker plans Contribute to translational biology strategy supporting future IND-enabling development Cross-functional Leadership Serve as a scientific leader across biology, platform, and therapeutic program needs Collaborate closely with chemistry, delivery, translational, regulatory, and external teams Help define scientific strategy for kidney therapeutic programs and platform evolution Data, Communication, and Documentation Maintain rigorous industry standard ELN documentation Present findings to internal research team, leadership & external partners Contribute to patents, publications, study reports, and data presentations Required Qualifications PhD in Nephrology, Renal Biology, Cell Biology, Molecular Biology, Pharmacology, or related field with 3-8+ years of relevant postdoctoral and/or industry experience Deep expertise and extensive hands-on bench experience in both in vitro and in vivo kidney biology, kidney disease mechanisms, and translational renal models Strong technical expertise in mammalian cell culture (including different kidney cells), qPCR/RT-qPCR, flow cytometry, ELISA/MSD, Western blot, immunostaining, advanced imaging, and functional assay development Excellent scientific communication, problem-solving, and collaborative skills Preferred Qualifications Hands-on experience in kidney therapeutics, nephrology, or precision medicine Direct experience with renal efficacy studies, PK/PD, biodistribution, or translational biomarker programs Experience with siRNA, ASO, mRNA, or nucleic acid therapeutics Experience with ligand-mediated or receptor-targeted delivery systems Prior startup biotech experience What We Are Looking For Builder mindset with excitement to create new platform Hands-on leader who enjoys bench work Strong problem solver comfortable with ambiguity in a startup environment Collaborative team player We are proud to be an Equal Opportunity Affirmative Action Employer. All applicants will be afforded equal opportunity without discrimination because of race, color, religion, sex, gender identity or expression, sexual orientation, marital status, order of protection status, national origin or ancestry, citizenship status, age, physical or mental disability unrelated to ability, military status or an unfavorable discharge from military service. If you share our passion for creating new cutting-edge therapies for patients in need, please apply via email to: jobs@raptormedicines.com. Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert