Type:

full-time

Job Description:

Senior Director, Discovery Biology Location:

Boston/Cambridge, MA Salary:

$212,000-$333,190/year + performance incentives

Industry:

Pharmaceutical / Biotechnology A senior scientific leadership opportunity is available for an experienced drug discovery professional to lead discovery biology strategy within an AI-enabled research environment. The role will establish the biological and translational foundation for programs, from target validation through clinical hypothesis, while integrating experimental biology with advanced data and AI-driven drug discovery approaches. Key Responsibilities Lead disease biology and target validation strategy across a portfolio of discovery programs Establish mechanistic rationale, differentiation and clinical relevance for therapeutic programs Define translational biomarker strategies to support program progression and go/no-go decisions Design and oversee external CRO biology programs, including in vitro and in vivo studies Critically evaluate scientific data and ensure study outputs are decision-ready Integrate biology data into AI-enabled drug discovery and design-make-test-analyze (DMTA) workflows Collaborate with medicinal chemistry, computational chemistry, DMPK, safety and structural biology teams Challenge scientific assumptions and ensure biological rigor throughout program development Represent biology strategy at governance and portfolio review forums Contribute to IND-enabling biology packages and regulatory development activities Monitor developments in disease biology and competitive research to inform portfolio strategy Help establish new operating models for AI-enabled discovery and research automation Requirements PhD in Cell Biology, Molecular Biology, Pharmacology or a closely related scientific discipline 12-15+ years of drug discovery experience Strong track record in target validation and disease biology Experience contributing to IND filings and IND-enabling biology packages Proven experience managing and overseeing external CRO biology programs Ability to connect target biology with translational strategy and clinical hypotheses Experience working with AI/ML-enabled data integration and large, multi-source datasets Expertise in at least one relevant therapeutic area Strong cross-functional leadership and collaboration skills Ability to operate effectively within a lean, fast-paced and highly innovative research environment

Compensation:

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