About the Job The overall objective of the lab is to understand the mechanisms modulating resistance to therapy and use the knowledge gained from these studies to develop novel therapies for glioblastoma. To this end, we utilize genome-wide screening to identify molecular modifiers of therapy sensitivity, especially to temozolomide (TMZ). We have already identified over six hundred potential druggable modulators of TMZ resistance. The post-doctoral fellow will perform secondary validation to identify the best candidates and use biochemical and pharmacological strategies to evaluate the mechanisms by which these candidates sensitize TMZ in glioblastoma cells in vitro and in vivo. The employer retains the right to change or assign other duties to this position. Focus of Job Responsibilities Experimental Design and Therapeutic Evaluation - 60%

• Conduct in vitro and in vivo studies to assess the efficacy of novel therapeutic targets, both alone and in combination with temozolomide and/or radiation.
• Investigate underlying mechanisms of action using a range of biochemical and pharmacological. Target Validation and Molecular Engineering - 20%
• Use sh

RNA/CRISPR

gene-targeting approaches to validate novel targets identified through secondary, custom-designed siRNA library screening. Laboratory Management and Scholarly Contribution - 15%

• Mentor research technologists, students, and/or interns.
• Prepare and contribute to manuscripts for publication.
• Participate in local and national scientific meetings.

Other Duties - 5% Flexible Work Profile The Research and Innovation Office (RIO) and The Hormel Institute endorses a "work with flexibility" approach that offers a welcoming and flexible work environment where everyone is inspired to do their best. Work location options include working fully remote, partially remote, or entirely in the office and are based on the work of the position. Some on-site work may be necessary for certain positions, even those designated as fully remote. Because we are a land-grant institution that serves the state, the University will continue to- in most cases- expect employees to live in Minnesota. This position has been designated as eligible for Flexible Work Profile One. Flexible Work Profile One, Office/Lab-Based - is expected to work primarily on-site in the office/lab. Only occasionally and inconsistently working remotely. Your office will be located at The Hormel Institute in Austin, Minnesota. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time. Qualifications Required Qualifications

• Ph.D., DDS, DVM, MD or equivalent. Preferred Qualifications
• Experience in molecular and/or cancer biology.
• Experience in next-generation sequencing, CRISPR/Cas9 technology, and in conducting flank and intracranial efficacy studies in animals (mice). Physical & Environmental Requirements
• Must be comfortable working in environments that may include close contact with animals, animal byproducts, and related materials.
• Exposure to varying temperatures, outdoor environments, and potential odors or airborne particles related to animal care.

About the Department Founded in 1942 by Jay C. Hormel and The Hormel Foundation, The Hormel Institute, University of Minnesota, makes scientific advancements that enhance wellbeing and extend human life. For more than 80 years, we have pursued our mission to conduct research and provide education in the biological sciences with applications in medicine and agriculture. A part of the University of Minnesota's Research and Innovation Office, The Hormel Institute partners with the region's leading biomedical research facilities, including Mayo Clinic.

Pay and Benefits Pay Range:

$62,232-$72,960 ; depending on education/qualifications/experience Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility. Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training Medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Disability and life insurance Employee wellbeing program Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost How To Apply Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section. To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647. Diversity The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the

U:

http://diversity.umn.edu Employment Requirements Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment. About University of Minnesota The University of Minnesota, Twin Cities (UMTC) The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations. At the University of Minnesota, we are proud to be recognized by Forbes as a Best Employer for Company Culture (2026), Best Employer for Women (2023), and Best Employer by State (2022-2026). In 2026, we also received Culture Excellence & Industry Awards recognition for employee appreciation and work-life flexibility.