PMID:

41932914 ; Advanced Sciences, 2022,

PMID:

35289120; and Cell Reports, 2021,

PMID:

34731628). The successful candidate will design and conduct experiments in both cell culture and animal models, develop and characterize siRNA-loaded nanoliposome formulations, and perform in vivo studies to evaluate biodistribution, target gene knockdown, therapeutic efficacy, and the translational potential of RNAi-based therapeutics for cancer treatment. Familiarity with protein structure and structure-function relationships will be considered an advantage for this position. Primary Responsibilities Plan, design and execute complex research studies, procedures and protocols. Participate in discovery projects. Knowledge on characterizing the role of RNA binding protiens on immune infiltrations in women's cancer Experience with cell biology and molecular biology methods (i.e., FACS, western blotting, RNA isolation, cDNA synthesis, Quantitative PCR) Isolation of immune infiltrates from tumor tissues Knowledge of basic methods such as tissue culture, transfections, western blotting, immunofluorescence and quantitative real-time PCR are required Capable of independent thinking, able to learn new techniques and have good presentation skills Experience in mouse experiments is required Coordinate research study activities; lead and manage projects. Oversee organization, synthesis and analysis of data and findings. Prepare scientific reports, outcome findings and scientific manuscripts. Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures. Knowledge - Skills - Abilities

Ph.D. in Cancer Biology, Molecular Biology, Cell Biology, Biochemistry, Pharmaceutical Sciences, Biomedical Engineering, or a closely related discipline.
Strong background in molecular and cellular biology techniques, including RNA biology, gene expression analysis, gene silencing, and CRISPR-based approaches.
Experience with mammalian cell culture, transfection, and functional assays to investigate cancer cell behavior and therapeutic responses.
Demonstrated expertise in in vivo mouse models of cancer, including tumor implantation, therapeutic administration, tissue collection, and animal handling.
Hands-on experience in the design, formulation, and characterization of lipid- or nanoparticle-based nucleic acid delivery systems is highly desirable.
Knowledge of RNA interference (RNAi), siRNA therapeutics, oligonucleotide chemistry, or other RNA-based therapeutic platforms, with an interest in translational cancer research.
Experience with biochemical and molecular techniques such as Western blotting, qRT-PCR, immunofluorescence, flow cytometry, ELISA, and confocal microscopy.
Ability to independently design experiments, analyze and interpret complex datasets, troubleshoot technical challenges, and effectively communicate scientific findings through publications and presentations.
Familiarity with protein structure, structure-function relationships, molecular modeling, or targeted protein degradation technologies (e.g., PROTACs) will be considered an asset.
Excellent organizational, interpersonal, and collaborative skills, with a demonstrated ability to work effectively in a multidisciplinary and highly collaborative research environment.

Qualifications Minimum Required Education:

PhD in a scientific field

Minimum Required Experience:

Recent Ph.D. and not more than 2 years of post-doctoral experience Physical Requirements Work requires occasionally lifting moderate weight materials, standing, or walking continuously. Work Environment Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment. Sensory Acuity Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects. MCW as an Equal Opportunity Employer and Commitment to

Non-Discrimination:

The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

Pay:

$60,000.00 - $62,000.00 per year

Benefits:

Dental insurance Health insurance Parental leave Vision insurance

Work Location:

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