Assistant Scientist - Bioconjugation Spectrix Analytical Services, LLC - 4.1 Brisbane, CA Job Details Full-time | Contract $32 - $35 an hour 19 hours ago Benefits Health savings account Health insurance Dental insurance 401(k) Flexible spending account Tuition reimbursement Paid time off Parental leave Employee assistance program Vision insurance 401(k) matching Professional development assistance Flexible schedule Life insurance Referral program Retirement plan Qualifications Teamwork Doctoral degree Protein analysis (analytical chemistry specialty) Handling antibodies Biochemical laboratory techniques Chemical separation processes Attention to detail Pharmaceutical analysis Materials analysis (analytical chemistry specialty) FPLC Laboratory quality control Chemistry Implementing quality control processes for products Cross-functional collaboration Organic synthesis Bioinformatics Cross-functional communication Full Job Description Company Overview Spectrix Analytical Services, LLC is a dedicated provider of on-site analytical scientific services, supporting research and development efforts across various industries. Since 1999, our talented scientists have delivered reliable, high-quality results by integrating seamlessly into our clients' laboratories to enhance their analytical capabilities. Position Summary The Bioconjugation group within Discovery Biotherapeutics is seeking a motivated, detail-oriented scientist to design, produce, purify, and characterize antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) in support of early-stage discovery programs. This is a hands-on laboratory role in which you will work both independently and as part of a multidisciplinary team to advance next-generation targeted therapeutics from concept through preclinical evaluation. Key Responsibilities Independently plan, execute, and troubleshoot laboratory experiments for the conjugation of ADCs and AOCs, including reaction optimization, purification, and analytical characterization of the resulting conjugates. Design, produce, and characterize ADCs and/or AOCs on the 1-100 mg scale, ensuring each conjugate meets established quality-control criteria: target conjugation ratio (e.g., drug-to-antibody ratio, DAR), purity, low aggregate content, endotoxin limits, etc. Optimize and develop new conjugation and purification workflows to improve reproducibility, efficiency, product quality, and scalability. Maintain thorough, accurate, and timely experimental records in the Electronic Laboratory Notebook (ELN), and register conjugates and upload supporting analytical data to the appropriate sample-tracking and data-management systems. Required Experience, Education and Specialized Knowledge and Skills Education & Experience Associate's or vocational degree with 3-5 years of relevant academic or industry experience; or Bachelor's degree with 1-3 years of relevant experience; or Master's degree with 0-1 years of relevant experience. Academic or hands-on background in one or more of the following: protein science, bioconjugation, analytical chemistry, organic chemistry, and/or chemical biology. Technical Expertise Hands-on experience handling proteins and antibodies, with working knowledge of common bioconjugation chemistries and workflows, including lysine (amine) conjugation, reduced inter-chain cysteine conjugation, and site-specific/engineered cysteine conjugation. Demonstrated ability to optimize and perform protein purification on Ä

KTA FPLC

systems across multiple chromatographic modes, including desalting, affinity, size-exclusion (SEC), and ion-exchange (IEX) chromatography. Demonstrated experience in the analytical characterization and quality control of antibodies and conjugates, using techniques such as analytical SEC (aSEC), reversed-phase HPLC (RP-HPLC), LC-MS (reaction monitoring, intact-mass analysis, and DAR determination). Hands-on familiarity with Agilent HPLC systems is desired. Core Competencies Excellent organizational, analytical, and technical problem-solving skills. Demonstrated initiative and innovative thinking, including a track record of implementing new experimental approaches and technologies. Proven ability to work effectively both independently and within a collaborative, cross-functional team environment. Excellent interpersonal and written/verbal communication skills, with the ability to prioritize and manage multiple projects simultaneously and a strong sense of urgency. Enthusiasm, intellectual curiosity, a strong work ethic, and broad scientific interests. Preferred Skills Experienced with Benchling ELN. Experience working with a variety of antibody and protein formats, including Fab-Fc, Fab, VHH (single-domain antibodies), and scFv. Working knowledge of common protein engineering strategies for conjugation, such as engineered cysteines or the incorporation of non-canonical amino acids for site-specific attachment. Experience with enzymatic conjugation methods (e.g., microbial transglutaminase-, glycan remodeling, or sortase-mediated conjugation). Spectrix is an equal-opportunity employer. We do not discriminate on the basis of race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Spectrix complies with all applicable federal, state, and local laws governing nondiscrimination in employment. Spectrix is participating in the E-Verify program of the U.S. Department of Homeland Security (phone number: 888-897-7781, and website: www.dhs.gov/E-Verify).

Job Types:

Full-time, Contract Pay:

$32.00 - $35.00 per hour

Benefits:

401(k) 401(k) matching Dental insurance Employee assistance program Flexible schedule Flexible spending account Health insurance Health savings account Life insurance Paid time off Parental leave Professional development assistance Referral program Retirement plan Tuition reimbursement Vision insurance

Education:

Doctorate (Required)

Experience:

Bioinformatics:

1 year (Preferred)

Work Location:

In person