Process Development Senior Scientist Employer Amgen Location Thousand Oaks, California Start date Aug 24, 2026 View more categories View less categories Discipline Engineering , Manufacturing & Production , Science/R D , Biotechnology Required Education Bachelors Degree Position Type Full time Hotbed Biotech Beach , Best Places to Work Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Company Job Details Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Process Development Senior Scientist What you will do Lets do this. Lets change the world. In this vital role you will have the opportunity to work on complex synthetic molecule platforms, including targeted protein degraders, PROteolysis TArgeting Chimeras (PROTACs), molecular glues, and other beyond-rule-of-5 compounds with challenging physicochemical and biopharmaceutical properties. The scientist will primarily design and execute formulation and process development studies for oral solid dosage forms, ranging from conventional oral solid dosage formulations to advanced enabling formulation strategies intended to overcome solubility, dissolution, absorption, and bioavailability limitations. The scientist will develop robust, scalable, and phase-appropriate formulations suitable for IND-enabling studies and GMP clinical manufacturing. This role provides significant opportunity to influence drug product strategy and advance next-generation oral delivery capabilities across Amgens synthetic molecule portfolio. The individual will work closely with internal manufacturing and external manufacturing partners to support process scale-up, GMP clinical manufacturing, technology transfer, and regulatory submissions. The scientist may support multiple fast-paced programs across oncology and other therapeutic areas with varying molecular and formulation complexities.

Key Responsibilities:

Serve as the Drug Product Team Lead and primary Drug Product functional representative on cross-functional synthetic molecule development teams Independently lead drug product development strategy and execution for early clinical synthetic molecule programs Lead and execute drug product development activities with a focus on right-first-time delivery, proactive risk management, and on-time achievement of program milestones. Design and execute formulation and process development experiments for oral solid dosage forms, including platform and enabling formulations Apply scientific understanding of material properties, biopharmaceutics, and manufacturability to formulation strategy selection and process development Identify technical risks, develop mitigation strategies, and drive solutions to support program timelines and clinical objectives Partner effectively across internal functions and external CMOs to support program execution, technology transfer, scale-up, and GMP clinical manufacturing Author and review technical and regulatory documentation including INDs, CTAs and related CMC submissions Present technical strategies, development plans, risks, and recommendations to cross-functional teams and governance forums Contribute to continuous improvement initiatives and advancement of formulation and process development capabilities What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is an individual with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Masters degree and 3 years of Scientific experience OR Bachelors degree and 5 years of Scientific experience

Preferred Qualifications:

Ph.D. in Pharmaceutical Sciences, Bioengineering, Chemical Engineering, Chemistry, or related scientific discipline with emphasis on oral drug product development for advanced synthetic modalities including degraders and PROTACs. Industry experience supporting early clinical drug product development programs preferred. Hands-on experience with enabling solubility formulation technologies including hot melt extrusion (HME), spray dried dispersions (SDD), and downstream processing for oral solid dosage forms. Experience supporting oral solid dosage form process development, scale-up, technology transfer, and GMP clinical manufacturing. Strong understanding of formulation development for poorly soluble compounds and enabling bioavailability enhancement strategies. Experience serving as a Drug Product or Formulation Development representative on interdisciplinary and multidisciplinary teams. Experience authoring regulatory documentation including INDs, CTAs, and related RTQs. Excellent interpersonal and verbal/written communication skills with demonstrated ability to manage complex cross-functional project activities. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Company We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world's leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide. We live the mission. We win together. We thrive on continual challenge. Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission. At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we're transforming the promise of science and biotechnology into therapies that have the power to restore health. Connect with us to explore how you can Win, Live, and Thrive at Amgen.

Company info Website http:

//careers.amgen.com/ Phone 805-447-1000 Location Corporate Headquarters One Amgen Center Drive Thousand Oaks California 91320-1799 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert Similar jobs Associate Director, Drug Product Manufacturing Waltham, MA Senior Scientist II ADC Reaction Engineer North Chicago, IL Process Development Engineer I, Purification Development Tarrytown, New York