Analytical Development Scientist (ADCs)

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Job ID:

10200047 Posted today Back Devens, MA, US Scientific Masters Degree Full Time, Direct Hire $100,000-130,000/year Experienced (Non-Manager) On-site Biotechnology/Pharmaceuticals First Shift (Day) Devens, MA, US $100,000-130,000/year Experienced (Non-Manager) Full Time, Direct Hire Biotechnology/Pharmaceuticals On-site Scientific Masters Degree First Shift (Day) Apply Now Applied Job details Kelly Science & Clinical is seeking Analytical Development Scientist (Antibody Drug Conjugates) to join a growing company located in Devens, MA.

Salary:

$100,000-130,000/year

Employment Type:

Full Time; Direct Hire •Relocation Assistance available for qualifying candidates•

Job Responsibilities:

Execute technical leadership in the planning and analysis of experiments for method development, validation, and product characterization in alignment with ICH guidelines. Develop, validate and optimize LCMS methods for the qualitative and quantitative analysis of Antibody Drug Conjugates (ADCs), specifically focusing on: Drug-to-Antibody Ratio (DAR) determination. Payload quantification for both free and conjugated forms. Linker stability and degradation profiling. Site-specific conjugation analysis. Perform intact mass analysis, peptide mapping, drug-to-antibody ratio (DAR) determination, and payload identification. Characterize Antibody Drug Conjugates (ADCs) for critical quality attributes including conjugation sites, linker stability, and degradation products. Support cGMP manufacturing through in-process and release sample analysis. Author documentation, including test methods, protocols, and regulatory filings. Maintain LCMS systems (Orbitrap, Q-TOF, Triple Quad) and lead troubleshooting efforts. Enforce safety and quality standards across all laboratory activities. Communicate findings to internal teams, clients, and regulatory bodies. Partner cross-functionally with Chemistry, QC, and Regulatory teams for project delivery. Mentor scientific staff to foster technical growth and knowledge sharing. Lead project priorities using strong organizational and leadership skills.

Qualifications:

Master's degree or PhD in Analytical Chemistry, Biochemistry, Chemical/Biomedical Engineering or a related scientific field. 4+ years of hands-on industry experience in analytical method development, validation and characterization of bioconjugates and utilizing LCMS instrumentation for analyzing biologics, preferably Antibody Drug Conjugates (ADCs).

Preferred qualification:

Experienced with CE-SDS, HIC, SEC, UV-Vis, fluorescence assays, and immunoassays (ELISA, ECL) for Antibody Drug Conjugate (ADC) analysis, including purity, DAR profiling, aggregation, payload quantification, and antibody detection. Interested? Please apply today for immediate consideration! 10200047 Share this job Copied url To save a job sign in or get started To apply for this job email your details to I want more jobs like this in my inbox.

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