Job Title:

Associate Director, CMC Lead Introduction to role: Are you ready to lead early-stage CMC strategy that turns precision radioconjugate science into first-in-human reality? As Associate Director, CMC Lead, you will steer development across a portfolio of alpha-emitting, tumor-targeted medicines, shaping IND-enabling plans and building the foundations for reliable, phase-appropriate clinical supply. Your decisions will determine how fast promising candidates move from discovery to patients. You will join a team pushing the boundaries of oncology through novel radioconjugates and smart combinations, supported by state-of-the-art radiopharmaceutical manufacturing capabilities and an advancing clinical pipeline. How will you prioritize across multiple candidates, balance scientific rigor with speed, and de-risk the path to first-in-human studies? If you thrive in a dynamic, matrixed environment and enjoy solving complex CMC puzzles, this role puts you at the center of impact.

Accountabilities:

Phase 0

CMC Strategy:

Define and deliver the pharmaceutical development strategy for the pre-IND/IND-enabling portfolio to drive timely progression to first-in-human readiness.

IND/IMPD

Readiness:

Lead CMC regulatory strategy; guide and contribute to authoring high-quality documentation and data packages for

IND/IMPD

submissions.

API/Drug Product/Analytical Integration:

Coordinate API, drug product, and analytical development to establish robust, scalable, phase-appropriate processes and methods.

Clinical Supply Strategy:

Build and execute supply strategies for Phase 0/Phase I, aligning isotope availability, shelf life, and study timelines to ensure on-time, fit-for-purpose clinical material.

Portfolio Leadership:

Manage multiple early-stage programs; set priorities, balance resources, and adjust strategies as data emerge to protect the critical path.

Cross-Functional Influence:

Represent CMC on project teams; shape overall program strategies and inform candidate selection through clear, data-driven risk/benefit assessments.

Target and Modality Assessment:

Evaluate new molecular targets and modalities for CMC feasibility and developability to guide investment decisions.

Transition Enablement:

Partner with Program Management, Clinical, Research, Regulatory, Quality, and Supply Chain to enable seamless movement of candidates from research into early development.

Essential Skills/Experience:

7+ years of experience in pharmaceutical/biopharmaceutical product development and manufacturing; Minimum education: Bachelor's degree. Advanced degree in Biochemistry, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, Chemical Engineering, or related scientific discipline preferred. Demonstrated experience managing early-phase CMC development, including IND-enabling activities, process development, and analytical method development. Strong project leadership skills with the ability to manage multiple concurrent programs at varying stages of maturity. Demonstrated strong interpersonal and communication skills with the ability to collaborate effectively across functions and influence stakeholders at multiple levels of the organization. Ability to develop and implement phase-appropriate pharmaceutical strategies across CMC areas (API, DP, Analytical) aligned with overall program objectives and timelines. Experience working in a matrix environment and leading cross-functional sub-teams to deliver against defined milestones. Strong problem-solving aptitude with the ability to navigate ambiguity and make sound technical and strategic judgments in a data-limited, early-stage environment.

Desirable Skills/Experience:

Experience with radiopharmaceuticals or radioconjugates, including awareness of radiochemistry constraints and alpha-emitting isotopes. Prior authorship or leadership of CMC sections for

IND/IMPD

filings for biologics, conjugates, or complex modalities. Familiarity with clinical supply strategies for short half-life or just-in-time manufactured products. Hands-on application of Quality by Design, design of experiments, and risk management in early development. Track record of successful tech transfer to GMP facilities and effective collaboration with external partners or CDMOs. Understanding of analytical method lifecycle, including phase-appropriate validation and control strategy development. The annual base pay (or hourly rate of compensation) for this position ranges from $136,514 USD to $204,771 USD. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Why AstraZeneca:

Here you will follow the science with the resources to act on it, working alongside radiochemists, data scientists, clinicians, and CMC leaders who challenge assumptions and unlock new solutions together. We invest deeply in understanding disease biology and harness digital, data science, and AI to better predict clinical success, accelerating promising assets without compromising quality. Expect an environment that values kindness alongside ambition, where bold ideas are welcomed, thoughtful risks are supported, and your expertise directly shapes how innovative medicines reach patients sooner. Call to

Action:

If you are ready to lead pivotal CMC decisions that bring precision radioconjugates to first-in-human studies faster, step forward and shape what science makes possible. #LI-Hybrid Date Posted 04-Aug-2026 Closing Date 30-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. 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