APPLY. A

complete application consists of: An application Transcripts - Click here for detailed information about acceptable transcripts A current resume/CV, including academic history, employment history, relevant experiences, and publication list One educational or professional recommendation All documents must be in English or include an official English translation. If you have questions, send an email to . Please include the reference code for this opportunity in your email. Connect with ORISE...on the GO! Download the new

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mobile app in the Apple App Store or Google Play Store to help you stay engaged, connected, and informed during your ORISE experience and beyond! Application Deadline Description •Applications will be reviewed on a rolling-basis.

FDA Office and Location:

A research opportunity is available immediately with the Food and Drug Administration (FDA), The National Center for Toxicological Research (NCTR) located in Jefferson, Arkansas. The National Center for Toxicological Research (NCTR), is the only FDA Center located outside the Washington D.C. metropolitan area. The one-million square foot research campus in Jefferson, Arkansas plays an important role in the missions of FDA and the Department of Health and Human Services to promote and protect public health.

Research Project:

You will contribute to a project investigating the performance of established and emerging liver toxicity biomarkers in two New Approach Methodology (NAM) platforms, including liver microtissues and liver-on-a-chip systems. The objective of this project is to develop translational biomarkers that can be reliably measured in NAMs to predict chemical-induced liver toxicity in humans. You will participate in experimental design, evaluate the toxicity of selected chemicals in NAM models, draft technical reports, meeting abstracts, and manuscripts, and gain experience conducting research within a regulatory agency. All activities you undertake will support efforts to protect and promote public health using advanced new approach methodologies.

Learning Objectives:

You will be trained to culture primary human liver cells using NAM platforms, treat cells with chemicals at human-relevant concentrations, and assess liver toxicity using approaches such as biochemical assays of enzyme activities. You will have unique opportunities to communicate research outcomes with those in regulatory agencies and to learn about the processes and pathways for biomarker and NAM qualification. Through this experience, you will gain the experience and skills needed to become an independent investigator in regulatory agencies, industry, or academia.

Mentor:

The mentor for this opportunity is Qiang Shi ( ). If you have questions about the nature of the research, please contact the mentor.

Anticipated Appointment Start Date:

November 2, 2026. Start date is flexible and will depend on a variety of factors.

Appointment Length:

The appointment will initially be for two years, but may be renewed upon recommendation of FDA and is contingent on the availability of funds.

Level of Participation:

The appointment is full time.

Participant Stipend:

The participant will receive a monthly stipend commensurate with educational level and experience.

Citizenship Requirements:

This opportunity is available to U.S. citizens, Lawful Permanent Residents (LPR), and foreign nationals. Non-U.S. citizen applicants should refer to the Guidelines for Non-U.S. Citizens Details page of the program website for information about the valid immigration statuses that are acceptable for program participation. This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits. Completion of a successful background investigation by the Office of Personnel Management is required for an applicant to be on-boarded at

FDA. OPM

can complete a background investigation only for individuals, including non-US Citizens, who have resided in the US for a total of three of the past five years. FDA Ethics Requirements If an ORISE Fellow, to include their spouse and minor children, reports what is identified as a Significantly Regulated Organization (SRO) or prohibited investment fund financial interest in any amount, or a relationship with an SRO, except for spousal employment with an SRO, and the individual will not voluntarily divest the financial interest or terminate the relationship, then the individual is not placed at FDA. For additional requirements, see FDA Ethics for Nonemployee Scientists . FDA requires ORISE participants to read and sign their FDA Education and Training Agreement within 30 days of his/her start date, setting forth the conditions and expectations for his/her educational appointment at the agency. This agreement covers such topics as the following: Non-employee nature of the ORISE appointment; Prohibition on ORISE Fellows performing inherently governmental functions; Obligation of ORISE Fellows to convey all necessary rights to the FDA regarding intellectual property conceived or first reduced to practice during their fellowship; The fact that research materials and laboratory notebooks are the property of the FDA; ORISE fellow's obligation to protect and not to further disclose or use non-public information. Qualifications The qualified candidate should be currently pursuing or have received a doctoral degree in the one of the relevant fields.

Point of Contact Eligibility Requirements Degree:

Doctoral Degree. Discipline(s): Chemistry and Materials Sciences (12 ) Communications and Graphics Design (2 ) Computer, Information, and Data Sciences (17 ) Earth and Geosciences (21 ) Engineering (29 ) Environmental and Marine Sciences (14 ) Life Health and Medical Sciences (51 ) Mathematics and Statistics (11 ) Physics (16 ) Science & Engineering-related (2 ) Social and Behavioral Sciences (29 ) Affirmation I am a U.S. citizen, or I have lived in the United States for at least 36 out of the past 60 months. (36 months do not have to be consecutive.) AND I have read the FDA Ethics Requirements. The

ORISE GO

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FDA Postdoctoral Fellowship - Hepatotoxicity in New Approach Methodologies