Job ID:

#10548 Contract Research Associate/Sr. Research Associate (Discover Chemistry) Burlington, MA Science Research & Development Position located in

Burlington, MA Responsibilities:

Perform routine laboratory functions and maintain, calibrate, and set up laboratory instruments and equipment. Perform synthesis of chemically modified oligonucleotides and peptides using automated instruments. Experience with MerMade/AKTA oligonucleotide synthesizers, and Liberty Blue/Aaptec peptide synthesizers desirable. Perform multi-step small molecule reactions to generate ligands for downstream bioconjugation projects. Work closely with senior scientists to design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.

Data management and documentation:

Maintain accurate, organized experimental records and reagent inventories in electronic lab notebooks (ELNs) on a regular basis. Act as member of a multidisciplinary research team, assisting with development of project strategy, analysis and communication of complex data.

Requirements:

B.S./M.S.

in chemistry or related fields with 0-4 years of relevant experience, preferably in an industrial setting. Experience in organic chemistry and multi-step organic synthesis Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is preferred Experience using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase, Ion exchange chromatography (HPLC/UPLC), ESI-MS and

MALDI-TOF

Mass Spectrometry (LC-MS) is a plus. Experienced in using electronic lab notebooks (ELNs) for data documentation and management. #IND1