Job Summary
The Senior Director, Biostatistics, provides leadership, oversight, and technical/scientific direction across multiple therapeutic areas.

This role leads and develops a high‑performing biostatistics team that delivers both strong scientific engagement and operational excellence throughout the clinical development lifecycle. Core responsibilities include trial design and development planning, statistical analysis strategy, modeling and simulation, regulatory submission support, advisory committee preparation, and scientific presentations.

Job Description
The Senior Director, Biostatistics plans, directs, and oversees the design, preparation, and execution of the biostatistical strategy supporting research and development, ensuring the appropriate application of sound statistical theory and methodologies across designated therapeutic areas.

In support of Clinical Development strategy, this role provides scientific review and oversight of key development materials, including but not limited to clinical protocols, statistical analysis plans, health authority submission documents, and publication materials. External scientific engagement is a core accountability of the role, including leadership of and participation in health authority interactions. Operational excellence is demonstrated through the effective and efficient delivery of the Clinical Development portfolio, including resource planning, prioritization, timeline management, and functional outsourcing. The Senior Director serves as a senior statistical subject‑matter expert and knowledge resource to cross‑functional project teams and acts as a point of escalation and resolution for biostatistical issues across relevant therapeutic areas. This role models and enables best practices for scientific engagement, fostering strong thought partnerships and a collaborative environment that encourages rigorous discussion and constructive debate. The individual cultivates a culture focused on goal achievement and personal accountability through clear expectations, ongoing performance monitoring, and course correction as needed. As a member of Biostatistics Leadership Team, the Senior Director balances innovation and intellectual curiosity with discipline and operational rigor. The role champions value‑added change, continuous improvement, and evolution of statistical practices, while inspiring and motivating others. The Senior Director ensures adherence to regulatory standards and industry best practices for statistical design, analysis, and reporting. The role also establishes and maintains external scientific relationships to remain current with emerging research, methodologies, and evolving regulatory expectations. This position is responsible for allocating resources to meet company and project needs without compromising scientific rigor or quality. The Senior Director directly supervises and develops biostatistics staff, including mentoring, training, performance management, and hiring.

Qualifications / Required Knowledge, Experience, and Skills
+ PhD in Statistics or Biostatistics with 12+ years of progressive experience in the pharmaceutical or biotechnology industry, including extensive involvement in clinical research and late‑stage development programs + Minimum of 5 years of demonstrated people leadership experience, including responsibility for hiring, developing, mentoring, and performance management of biostatistics professionals + Deep and end‑to‑end understanding of the clinical development process, from study design and development planning through regulatory submission (e.

g., NDA/BLA) and post‑submission activities + Strong working knowledge of global regulatory and industry best practices, including protocol and SAP development, statistical interpretation, and health authority expectations + Demonstrated experience supporting development programs across multiple therapeutic areas, with the ability to rapidly develop subject‑matter understanding in new disease areas + Proven expertise in state‑of‑the‑art statistical methodologies supporting clinical study design and analysis, including application of innovative or complex methods where appropriate + Strong foundation in statistical principles and applications, including modeling and simulation, and the ability to provide strategic technical guidance beyond routine analyses + Advanced proficiency in SAS and related statistical programming concepts, with sufficient technical depth to meaningfully review, challenge, and guide analytic work + Proficiency in standard business applications, including MS Office (Word, Excel, PowerPoint, Outlook), with the ability to communicate complex statistical concepts clearly to diverse audiences + Demonstrated ability to apply organizational policies and procedures effectively across complex and ambiguous situations, exercising sound judgment and leadership + Excellent communication, interpersonal, and leadership skills, with a proven ability to influence cross‑functional stakeholders, foster collaboration, and represent Biostatistics effectively at senior levels

Competencies
Accountability for Results
Stay focused on key strategic objectives, be accountable for high standards of performance, and take an active role in leading change.
Strategic Thinking & Problem Solving
Make decisions considering the long-term impact to customers, patients, employees, and the business.
Patient & Customer Centricity
Maintain an ongoing focus on the needs of our customers and/or key stakeholders.
Impactful Communication
Communicate with logic, clarity, and respect. Influence at all levels to achieve the best results for Otsuka.
Respectful Collaboration
Seek and value others' perspectives and strive for diverse partnerships to enhance work toward common goals.
Empowered Development
Play an active role in professional development as a business imperative. Minimum $230,720.00
Maximum $345,000.

00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate's job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws.

Application Deadline
: This will be posted for a minimum of 5 business days.
Company benefits:
Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits.

Come discover more about Otsuka and our benefit offerings; https://www.otsuka-us.com/careers-join-otsuka .

Disclaimer:
This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position.

It is not intended to include every job duty and responsibility specific to the position. Otsuka reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Otsuka is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic. If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation, if you are unable or limited in your ability to apply to this job opening as a result of your disability. You can request reasonable accommodations by contacting Accommodation Request (EEAccommodations@otsuka-us.com) .

Statement Regarding Job Recruiting Fraud Scams
At Otsuka we take security and protection of your personal information very seriously.

Please be aware individuals may approach you and falsely present themselves as our employees or representatives. They may use this false pretense to try to gain access to your personal information or acquire money from you by offering fictitious employment opportunities purportedly on our behalf. Please understand, Otsuka will

never
ask for financial information of any kind or for payment of money during the job application process.

We do not require any financial, credit card or bank account information and/or any payment of any kind to be considered for employment. We will also not offer you money to buy equipment, software, or for any other purpose during the job application process. If you are being asked to pay or offered money for equipment fees or some other application processing fee, even if claimed you will be reimbursed, this is not Otsuka. These claims are fraudulent and you are strongly advised to exercise caution when you receive such an offer of employment. Otsuka will also never ask you to download a third-party application in order to communicate about a legitimate job opportunity. Scammers may also send offers or claims from a fake email address or from Yahoo, Gmail, Hotmail, etc, and not from an official Otsuka email address. Please take extra caution while examining such an email address, as the scammers may misspell an official Otsuka email address and use a slightly modified version duplicating letters. To ensure that you are communicating about a legitimate job opportunity at Otsuka, please only deal directly with Otsuka through its official Otsuka Career website https://vhr-otsuka.wd1.myworkdayjobs.com/en-US/External . Otsuka will not be held liable or responsible for any claims, losses, damages or expenses resulting from job recruiting scams. If you suspect a position is fraudulent, please contact Otsuka's call center at: 800-363-5670. If you believe you are the victim of fraud resulting from a job recruiting scam, please contact the FBI through the Internet Crime Complaint Center at: https://www.ic3.gov , or your local authorities. Otsuka America Pharmaceutical Inc., Otsuka Pharmaceutical Development & Commercialization, Inc., and Otsuka Precision Health, Inc. 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