Sr Manager, Statistical Programming

Sr Manager, Statistical Programming Alnylam Pharmaceuticals paid time off United States, Massachusetts, Cambridge 675 West Kendall Street (Show on map) May 13, 2026 The Senior Manager Statistical Programming will provide leadership and expert-level hands-on support to programmers. The senior manager may also guide the professional development of statistical programmers within the company.

The position requires a broad, comprehensive and detailed understanding of statistical programming languages and software, industry best practices, clinical trial databases, regulatory filings, and pharmaceutical drug development. Summary of Key Responsibilities Oversees the work of internal statistical programmers.

Provides technical guidance and mentoring; Provides timely support to study teams on all programming matters according to productstrategies; Performs, plans and coordinates project work to ensure timely, quality delivery across multiple projects; Contributes to strategic initiatives to improve departmental processes and scalability; May function as lead programmer to produce or validate tables, listings, figures and analysis datasets; Writes specifications to describe programming needs; Creates and validates global macros or systems that streamline repetitive operations to increase programming efficiency; Keeps abreast of current and new statistical programming techniques and other applicable technical advancements while assisting in their implementation; Provides input into, or leads general standardization efforts (e.g., CRFs, query checks, standard statistical programs, data presentations); Assists in developing programming processes consistent with industry best practices; Reviews DMP, eCRF specs, and other clinical data management documents; Reviews statistical analysis plans and other related documents; Partners with or oversee CROs or Programming vendors to perform any of the above tasks; Other duties as assigned. Qualifications At least 8 years' industry (Pharmaceutical, Biotech, CRO) SAS programming experience or equivalent; At least 2 years management experience; Knowledge of clinical trials and experience in using SAS to report the results of clinical trials and/or integrated analysis for submission; Experience in constructing technical programming specifications and producing validated SAS programs Strong experience in working with CDISC standards, including SDTM, and ADaM and define documentation; Excellent knowledge of applied statistical methodologies; Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and

SAS/STAT

; Good communications and organizational skills required; Bachelor's Degree required, Master's Degree Preferred. Clear alignment with

Alnylam Core Values:

Commitment to People Innovation and Discovery Sense of Urgency Open Culture Passion for Excellence Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment. U.S. Pay Range $155,600.00 - $210,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. >