Your primary duties will be to build reproducible, testable, sequential data-assimilating digital twin workflows under the direction of Dr. James A. Glazier. You will implement patient-specific forecasting and rebasing pipelines, design anomaly-detection and residual-monitoring logic, infer unobserved state parameters, manage complex model ensemble interfaces, and coordinate computational infrastructure with national consortium collaborators. 60%

Digital Twin Workflows & Data Assimilation:

Develop Python workflows for short-horizon forecasting and patient-specific rebasing; implement data-assimilation methods (Kalman/Bayesian updating); design anomaly detection and missing-information inference logic. 40%

Software Engineering & Integration:

Build reproducible computational packages(CI/CD, containers, testing); manage ensemble interfaces; integrate workflows with external consortium platforms (Vivarium, QSP); write technical publications. Basic Qualifications Ph.D. or equivalent terminal degree in quantitative, computational, or biomedical discipline. Programming proficiency in Python, Julia, R, or MATLAB; background in mechanistic modeling (ODE/dynamical systems, QSP, or agent-based); familiarity with inflammation, cytokine signaling, sepsis, or critical care biology. One year of successful postdoctoral research experience. Department Contact for Questions Please contact Professor James Glazier at glazier@iu.edu with questions regarding the position. Additional Qualifications Salary and Rank 100,000/Assistant Scientist Special Instructions For Best Consideration Date 11/02/2026 Expected Start Date Posting Number IU-101733-2026