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Chemist
Cambridge, MA
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Principal Scientist Chemistry, Small Molecule Process Development and Manufacturing
Pay: $189,000/yr
Posted: 3 days ago
Location: Cambridge, MA (Onsite)
Last Updated: 1 day ago
Hours: Full-Time
Expires: 12/9/2026
Job Description
About This RoleWe are seeking a highly motivated and creative Chemist to join our Small Molecule Chemical Development team. This position provides an exciting opportunity to lead and mentor scientific and engineering teams in the development of robust processes for the synthesis of a wide range of Small Molecules across various modalities. This Principal Scientist, Chemistry position provides experiences in early phase to late phase drug development and exposure to the design and development of manufacturing processes for clinical and commercial therapeutics.
Who We AreWe are a team of organic chemists and chemical engineers engaged in the design of innovative processes which supply new medicines to patients. We focus on developing safe, economical, sustainable, cost-effective, and robust processes to support clinical trials and the launch of new medicines across various drug modalities. We are driven by first principles science, data-driven decision-making, and collaborative teamwork.
WhatYou'llDoLead collaborative development for manufacturing teams to design and conduct laboratory experiments to optimize and characterize the processes of Biogen assets, with an emphasis on improvement in process understanding, robustness, and productivityDesign and lead experimental planning to advance the Biogen portfolio. You will be responsible for leading project teams towards the implementation of safe, efficient and robust chemical processes of Biogen drug candidatesResponsible for mentoring less experienced staff by promoting the use of key laboratory instrumentationDevelop the fundamental process knowledge needed to support the transition of chemical and biochemical processes from laboratory scale to manufacturing partnersCollaborate with our Process Chemistry, Analytical Chemistry, Solid Form, Oligo, and Separations colleagues to develop the knowledge and controls needed for the supply of clinical materials and characterization of the process to support regulatory filingsCommunicate project team research results effectively in team meetings, including engagement in CMC activities including authoring CMC section of INDsInteract with Contract Research and Manufacturing Organizations as project needs evolve, which may include travelInitiate innovative research projects to improve fundamental understanding and control of Biogen processesExpand on your external presence professionally representing Biogen externally in consortia and conferencesEngage, mentor, and prepare our future leadersWho YouAreYou have a passion for exploring novel scientific concepts and are eager to contribute to the design and development and execution of cutting-edge technologies in the service of delivering drug candidates for clinical trials. Your vision and dedication drive you to push the boundaries of scientific endeavors, ultimately impacting patient lives. You thrive in a collaborative environment where urgency, accountability, inclusion, and integrity are shared values.
Required QualificationsPh.D. with 8+ years of relevant experience.
M.S. with 10+ years of relevant experience in pharmaceutical or biotech settings.
BS with 12+ years of relevant experience in pharmaceutical or biotech settingsStrong background in the theory and practice of pharmaceutical chemistry, including demonstrated understanding of route scouting, mechanistic experiments, experience with process characterization, familiarity with process safety and tech transfer protocols, and effective problem solving skillsExperience with piloting, manufacturing, and isolation of APIs across several modalities is preferred, as well as familiarity with analytical tools and various purification techniques.
Experience with CDMO managementStrong communication skills and a desire to thrive in a collaborative, team-oriented environment
Job Level:
ManagementAdditional InformationThe base compensation range for this role is: $159,000.00-$219,000.00Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:
Medical, Dental, Vision, & Life insurancesFitness & Wellness programs including a fitness reimbursementShort- and Long-Term Disability insuranceA minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)Up to 12 company paid holidays + 3 paid days off for Personal Significance80 hours of sick time per calendar yearPaid Maternity and Parental Leave benefit401(k) program participation with company matched contributionsEmployee stock purchase planTuition reimbursement of up to $10,000 per calendar yearEmployee Resource Groups participationWhy Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
Read onto learn more about Biogen.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
VEVRAA Federal Contractor.
We request Priority Protected Veteran & Disabled Referrals for all of our locations within the state.
PDN-a32a161f-75fe-4be5-8ed6-4e714bf8da51
Benefits
Paid Time Off (PTO)
Sick Leave
Financial Aid/Assistance
Employee Stock Options (ESOs)
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