Manager, Site Budgets & Contracts, Clinical Operations

Manager, Site Budgets and Contracts, Clinical Operations Who we are: At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture

• one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion
• because our differences shape how we hire, collaborate, and innovate. Our team's proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific
• it's deeply personal, grounded in the meaningful connections we have built.

To learn more, visit www.agios.com and follow Agios on LinkedIn and X .

The impact you will make:

Agios Pharmaceuticals is searching for a dynamic Manager, Site Budgets and Contracts to join our growing clinical operations team. The Manager will be responsible for executing all aspects of the clinical site contracting, negotiation and execution of required budgets and agreements in support of clinical studies. The role will coordinate activities across CROs, study sites, study teams, and internal stakeholders (Legal, Finance, Compliance) to effectively deliver negotiated site agreements that balance risk and budget, while understanding and achieving key deadlines.

What you will do:

In close partnership with the CROs and leveraging their regional and local expertise, while working with internal Agios colleagues, develop standard site budget templates using industry grant benchmarking software and leveraging budget precedent whenever possible. Oversee and partner with CRO on site negotiations while ensuring fair market value (FMV). Proactively identify risks with clinical site budgets, develop risk mitigation plans, and escalate appropriately during the negotiation process including direct negotiation with sites as needed. Maintain oversight of CROs to ensure compliant and timely execution of budget amendments. Meet tight study deadlines ensuring sites/PI contracts meet Ready to Enroll (RTE) Targets Ensure consistent approach to site budgets across studies/programs. Resolve site budget inquiries from stakeholders, i.e., Study Teams, CRO team members and Site/PIs with a sense of urgency and understanding importance of deadlines. Work with CRO and Agios Legal to generate approved study agreement templates. Leverage existing master and historical site agreements and CRO expertise wherever possible. Act as the first level of support for contract language escalations. Leverage Agios-approved fallback language and positions to expedite execution of an approved agreement. Escalate to and work with Legal to identify alternatives for any contract language that falls outside of approved language. Coordinate and track the contracting activities across Agios studies during startup. Act as single point of contact for the CROs and liaise between Legal, CROs and sites. Maintain oversight of CROs to ensure compliant and timely execution of site contracts and contract amendments. Develop and manage the overall CTA timeline, track progress and provide regular updates to key stakeholders. Provide a portfolio level view across all studies. Provide high level of customer service to PIs, Sites, CROs and Agios internal colleagues Identify process improvements and innovative approaches to the site contract/budget process. Support negotiation of other vendor agreements or investigator-sponsored trials if requested.

What you bring:

Bachelor's degree required Five plus (5+) years' experience in the biotechnology/pharmaceutical industry with at least 3 years of direct experience negotiating site budgets and contracts across late phase clinical studies in both the US and internationally. Deep experience in negotiations, managing CROs and creative and compliant conflict resolution and problem-solving. Thorough understanding of Clinical Operations, GCP, relevant ICH standards, and FDA/EMA guidelines. Deep understanding of site budget structure, including key cost drivers and common negotiation sticking points. Knowledge of and experience working with site contracts and common legal terms and conditions. Experience using outputs from trial cost benchmarking software. Ability to prioritize needs and handle a high volume of tasks within tight clinical timelines. Ability to build networks and collaborate with CRO and internal stakeholders. Concerned that you don't check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other's differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you're excited about this role but your previous experience doesn't align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening!

Work Location:

Location Agnostic:

Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance of our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate to the above job description.

What we will give you:

Deliberate Development. Your professional growth as one of our top priorities. Flexibility. We're all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you're at your best, we're at our best. Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website. Competitive and equitable performance-based compensation. This includes base salary and both short

• and long-term incentives that are connected to our business strategy and vary based on individual and company performance.

The current base salary range for this position is expected to be between $110,000 and $165,000 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries. Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We're continuously looking to improve the inclusivity of our workforce. Commitment to community. We're an active participant in the communities that surround us

• the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.