Who We Are BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions. Guided by our purpose to develop medicines that make a profound impact on people's lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions. Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world. About Technical Operations BioMarin's Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin's cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Role Summary Hybrid Position, requires 2 days onsite/ per week in San Rafael, CA (HQ) The Senior Director, Integrated Planning & Analytics, leads enterprise planning across demand, supply, inventory, capacity, and financial objectives through Integrated Business Planning (IBP). This role drives profitable growth, operational agility, and patient-centric outcomes across a global rare disease supply network by connecting decisions across Commercial, Clinical, Manufacturing, Quality, Regulatory, Medical Affairs, and Finance. In a dynamic portfolio shaped by new indications, label expansions, named-patient and compassionate use programs, and clinical-to-commercial transitions, this leader strengthens supply resilience, manages risk, and builds planning capabilities for long-term growth. As the global process owner for IBP, you will lead forward-looking decision-making across a 24-60-month horizon, including long-range capacity planning and modeling, inventory strategy, and data analytics that support reliable supply and patient access. Key Responsibilities 1. IBP Process Ownership in a Rare Disease Environment Own the global IBP framework for rare disease planning, addressing demand variability, small batches, long lead times, and constrained capacity. Establish and maintain a consistent IBP cadence (Product Review, Demand Review, Supply Review, Integrated Reconciliation, Executive IBP). Own the S&OE (Sales & Operations Execution) process, ensuring near-term demand, supply, and inventory decisions are aligned to the broader IBP framework and escalated appropriately. Embed patient-centric planning principles into the IBP cycle (e.g., emergency orders, compassionate use, urgent clinical supply requests). Ensure seamless integration of clinical and commercial planning due to overlapping supply sources and shared manufacturing assets. 2. Rare Disease Demand, Supply & Inventory Integration Oversee reconciliation of commercial, patient, named-patient, early-access, and clinical trial demand signals. Ensure supply plans reflect long cycle times, yield variability, cold-chain requirements, and CMO dependencies. Lead Inventory Management to define inventory policies, targets, and positioning strategies that minimize expiry while guaranteeing immediate patient access for ultra-low-volume therapies. Lead risk-based scenario planning for demand surges (e.g., new diagnoses, outbreaks, compassionate use clusters), supply disruptions, or single-source component issues. 3. Cross-Functional Leadership & Governance Chair IBP forums across Commercial, Clinical Operations, Technical Operations, Manufacturing, Quality, Regulatory, Finance, and Medical. Establish governance and decision rights for trade-offs such as allocation priorities, safety stock strategies, and launch readiness. Lead structured decision-making in Executive IBP, ensuring senior leaders have clear scenarios, risks, and recommendations. Drive alignment across global, regional, and country planning, accounting for reimbursement and access variability. 4.

People Leadership:

Lead the team of Integrating Planning & Analytics professionals, through strong development and mentoring while creating a culture of high accountability and innovation. Ensure there are departmental performance goals and objectives that the team of integrated planners can leverage to develop their respective objectives and provide performance feedback related to business objectives. Create a training curriculum to support Integrated Planning & Analytics Team's development responsibilities. Influence teams across the supply chain planning organization to improve their maturity and collaboration through a harmonized integrated planning playbook maximizing optimal support to the planning cycles. 5. Financial & Portfolio Integration Partner closely with Finance, particularly during AOP/LRP cycles, to embed operational, revenue, COGS, and margin considerations into IBP. Integrate portfolio plans including new indications, lifecycle extensions, label expansions, and transitions from clinical supply platforms to scaled commercial supply. Support business case development for strategic investments (redundant capacity, alternate sites, new technology platforms) and lead long-range capacity planning/modeling to ensure the network can support future portfolio growth, new indications, and evolving patient demand. 6. Data, Systems & Analytics Leading and enhancing performance management and visualization efforts, specifically improving dashboards that can be used across markets, supply, finance, and overall performance management Define the IBP technology vision with Digital/IT, including platforms for complex, low-volume, high-variability planning. Ensure data quality for critical demand, therapy, batch, expiry, and distribution attributes. Lead Data Analytics to develop advanced planning insights, improve forecast ability of ultra-small populations, and evaluate risk-based scenarios for proactive decision-making. 7. Stakeholder Engagement & Change Leadership Drive adoption of IBP behaviors in a highly cross-functional, mission-driven rare disease culture. Communicate clearly with senior leadership on risks, trade-offs, and opportunities, always emphasizing patient impact. Build planning capability across global and regional teams and mentor planners supporting rare disease products. Function as an internal expert and thought leader on best-practice

IBP/S&OP

for rare disease and biologics.

KPIs & Metrics:

This role will influence:

Patient & Service Metrics Supply Reliability Metrics Inventory & Waste Metrics Forecast & Financial Metrics IBP Process Health Metrics Qualifications Required:

Bachelor's degree in Supply Chain, Engineering, Business, Life Sciences, or related field. 12+ years of progressive supply chain or operations leadership in biotech, pharmaceutical, or rare disease environments. Proven leadership of global

S&OP/IBP

processes, including long-range capacity planning, inventory strategy, and executive decision support. Strong command of ERP, advanced planning systems, and analytics tools that support scenario modeling and business decisions. Demonstrated success leading through senior executives in complex, matrixed global organizations. Deep understanding of life science supply chains, including access variability, long lead times, biologics complexity, and patient-critical supply continuity. Strong financial acumen with proven cross-functional leadership in matrixed organizations.

Preferred:

Master's degree (MBA, MS, or equivalent). Experience with biologics, gene therapy, enzyme replacement therapies, or other complex rare disease modalities. APICS/ASCM, SCOR-P, or equivalent certification. Experience integrating clinical and commercial supply processes. Familiarity with global regulatory / GxP constraints uniquely impacting rare disease therapies. Core Competencies Patient-Centric Mindset — prioritizes therapy availability for individuals with life-altering conditions. Strategic Systems Thinking — understands complex network interactions across clinical and commercial supply, including long-range capacity and inventory trade-offs. Executive Influence — builds alignment, shapes decisions, and leads cross-functional forums with credibility in complex matrix environments. Data Analytics & Financial Acumen — translates operational scenarios into financial and patient impacts using data-driven insights and advanced planning analytics. Inventory Strategy — balances service, waste, and working capital through thoughtful inventory policy, positioning, and risk management. Risk Management — proactive identification and mitigation of rare disease supply vulnerabilities. Change Leadership — able to embed new planning behaviors, tools, and processes in a global organization. Travel Requirements International travel (10-25%) to manufacturing sites, affiliates, clinical hubs, and global planning workshops.

Note:

This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.