Computational Protein Engineer

Computational Protein Engineer

LOCATION

Rockville, MD No Remote TYPE Direct Hire ID PA78-2754747 POSTED May 6, 2026 Our client is a leading biotech firm advancing innovative antibody and protein engineering programs. They seek a Senior Scientist, Protein Engineering to lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles. The ideal candidate will take on the following responsibilities: Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design Drive protein expression, purification, and characterization workflows across multiple formats Design and execute binding and functional assays to evaluate and iterate on engineered proteins Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies Manage CRO partnerships including experimental design, vendor communication, and internal reporting The ideal candidate will possess the following qualifications: PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience Hands-on expertise in protein expression, purification, and characterization Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities Peer-reviewed publications and/or patents in antibody or protein engineering Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus Proven ability to lead technical teams and manage complex, multi-faceted projects Outstanding written and verbal communication skills