Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Executive Director, Clinical Scientist, supports the development and execution of clinical trials for assets targeting Metabolic dysfunction-associated steatohepatitis (MASH). Reporting to the VP of Clinical Development, this role will help drive the scientific strategy, clinical trial design, and data interpretation for one or more programs in the MASH portfolio. The ideal candidate has experience in clinical development, a strong understanding of clinical trial execution, and a passion for advancing therapies in liver and metabolic diseases. This position will require close collaboration with cross-functional teams and external partners to ensure scientific rigor and high-quality clinical data. Key Responsibilities Providing strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestone, the Executive Director, Clinical Scientist will: Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria. Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions. Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support. Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity. Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team. Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations. Stay current on therapeutic area trends, competitive landscape, and regulatory guidance related to MASH/NASH and associated comorbidities. Participate in cross-functional meetings and contribute to development strategies and timelines. Experience and Professional Qualifications The ideal candidate will bring deep clinical development experience and scientific expertise, with a track record of advancing programs through clinical stages and working effectively in cross-functional, matrixed environments. Experience and key requirements for the role include: Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master's with relevant experience may be considered. 12+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry. 18+ years relevant experience. Prior experience in liver disease, metabolic disorders, or

MASH/NASH

strongly preferred. Solid knowledge of ICH/GCP and global clinical trial regulations. Demonstrated ability to synthesize complex scientific data and present it clearly and effectively. Excellent verbal and written communication skills. Collaborative mindset with strong organizational and project management abilities.

Preferred Attributes:

Experience working in a fast-paced biotech environment with small, agile teams. Familiarity with liver disease endpoints such as histology, imaging, or non-invasive biomarkers. Experience supporting regulatory interactions or submissions is a plus. Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $288,000 - $352,000 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals' Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal's name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.