Histotechnician, 2nd Shift (Mon

• Fri) Personalis $40.

00 to $50.00 tuition reimbursement, 401(k) United States, California, Fremont Sep 16, 2026 At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

Under the direction of the department supervisor, technical/clinical consultant, and laboratory director, the Histotechnician will be responsible for processing FFPE specimens for microscopic evaluation to support our molecular diagnostics test offerings.

Available Shift:

• Monday
• Friday, 2:00pm
• 10:30pm

Responsibilities:

Perform sectioning of tissue using a microtome and mounting on glass slides

Perform routine staining of tissue sections with automated and/or manual staining techniques

Perform automated and/or manual coverslipping of slides

Generate digital slide images for pathologist examination

Perform manual and automated macrodissection

Operate and perform instrument maintenance

Perform histology lab functions while following laboratory safety and quality policies

Comply with standard laboratory operating policies and procedures

Use of good documentation practices to record specimen data manually or in Laboratory Information Management Systems

Help meet TAT goals while maintaining high-quality productivity

Maintain clean and organized work areas within the laboratory

Report problems to the department supervisor/manager to ensure timely resolution

Requirements:

• Associate's degree in chemical/physical/biological science or completion of a NAACLS-accredited Histotechnology program; Bachelor's degree in a laboratory science curriculum preferred
• Minimum of 3+ years experience working in a high-volume histology laboratory performing microtomy of various tissue types, H&E staining, and tissue embedding
• HT or HTL certification from ASCP
• Experience working in IHC and digital imaging, tissue/tumor identification, and proficiency in reading pathology reports, a plus
• Excellent attention to detail, organization, and time management skills
• Ability to communicate effectively with excellent interpersonal skills

Physical demands include stooping, turning, bending, squatting, kneeling, and the ability to lift up to 25 lbs. The hiring range for this position is $40.00 to $50.00 per hour, which may factor in various geographic regions. This shift is eligible for a shift differential pay bonus. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered. Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contact you.

Protecting Our Candidates:

At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) #LI-JT1 #LI-Onsite