POSITION SUMMARY

The VP, Global GMP Quality position will be responsible for leading the GMP quality functional teams at Mirum and its subsidiaries (US and International). This position will play a pivotal role in steering the organization toward an ongoing commitment to quality improvement, driving efforts to identify areas for optimization, innovation, and excellence. This person will be responsible for managing, mentoring and supporting a GMP Operations team of clinical and commercial Quality Assurance (QA) and Quality Control (QC) professionals. This person will provide leadership and hands-on support to ensure the seamless execution of GMP QA and QC functions, including product quality complaint investigation, root-cause investigations, and the reporting of critical GMP issues to executive management. This person will also be responsible for leading, providing direction, resources, and guidance to ensure that all GMP quality processes are executed with the highest standards of compliance with FDA, EMA, and other international regulatory requirements, corporate objectives, and industry best practices. This role also involves ensuring that the GMP and GDP quality functions are closely aligned with the organization's broader strategic goals, guaranteeing that quality initiatives support the company's mission, vision, and operational objectives.

JOB FUNCTIONS/RESPONSIBILITIES

Serve as the GMP quality strategic leader to assist the head of quality to further develop the quality culture at Mirum to be compliant, collaborative and phase appropriate. Develop and execute a global GMP quality strategy to align with corporate goals and regulatory requirements. Serve as the GMP quality strategic leader within the Quality group to lead the GMP QA and QC functional teams in fostering professional development and guiding staff in all aspects of GMP/GDP competence in meeting domestic and international regulatory requirements and guidelines (FDA, EMA, MHRA, NMPA, ICH, etc.). Lead the development and optimization of key processes, functional collaboration, transformational initiatives, and operational excellence through the GMP/GDP Quality Unit. Serve as the GMP quality lead in Audits and Regulatory Inspections in providing strategic leadership, interactions, responses, CAPA plans and implementation. Lead the GMP inspection readiness for the Company including GMP Quality improvement and maintenance. Host/Manage

GMP PAI/PLI

inspections at Mirum and support Mirum PAI/PLI related CMO inspections. Drive corporate values, vision, goals, and objectives through collaboration with senior leaders building cross-functional networks to influence operational capabilities. Serve as a GMP Quality advisor to cross-functional stakeholders within Mirum global organizations and subsidiaries. Promote collaboration across internal and external functional teams and stakeholders to identify, design and implement opportunities for improvement across all areas of GMP and GDP quality responsibilities. Establish, maintain, and ensure effectiveness of GMP and GDP quality programs and documentation to assure GxP compliance in the domestic and international regulatory environment. Oversee, support and perform all aspects of GMP QA and QC activities and functions for drug manufacturing to ensure product quality and supply chain integrity. Oversee and support all aspects of clinical and commercial product release which includes direct to market, partner and distributor. Serve as the Material Review Board (MRB) chair-person designee. Develop and execute a global recall strategy that integrates domestic and international recalls. Serve as the Recall Coordinator in the recall committee and support the recall/mock recall process. Collaborate with Commercial Organization on launch strategies, NPP/EAP/CUP programs and provide input as a Quality SME. Review and approval of GMP, GDP, Partner and Distributor Quality/Technical Agreements. Oversee the review and approval of APQR generation in a timely fashion. Assess the outcome of GMP audits at CMOs, CTLs, Partners, etc. for a holistic view and to partner with the Technical Operations team in driving improvements. Provide strategic and managerial leadership related to company objectives & initiatives and changing regulatory requirements to build, manage, and mentor high-performance QA and QC teams in a global environment. Oversee product launch, manufacturing, and distribution quality processes. Lead a culture of quality excellence, compliance, and continuous improvement across the organization. Ensure global GMP Quality Team meets stakeholder needs, focusing on efficiency, quality, budget management, and corporate growth. Serve as Quality Head designee for other GXP areas beyond GMP and GDP as required. Requires 15% domestic and international travel, at minimum.

QUALIFICATIONS

Education /

Experience:

Bachelor's degree in biochemistry, chemistry, biology, or other science related field (Advanced degree preferred). 15+ years of progressive Quality Assurance experience in pharmaceutical and/or Biotech industries, with at least 10+ years in quality leadership role and/or people management including direct & indirect reports. Demonstrates extensive knowledge of cGMP manufacturing and Quality Management in compliance with FDA (CBER and/or CDER) and EMA requirements for global-regulated products. Demonstrates extensive knowledge of the development and commercialization of medical device in compliance with FDA 21CFR820, ISO13485 and EMA MDR regulations Comprehensive knowledge of GMP, GDP, ISO, ICH, and global regulatory requirements. Product lifecycle including Late-stage drug development, Regulatory (NDA, MAA, BLA, etc) submission and commercial manufacturing experience. Experience with hosting and preparing for inspection readiness and an ability to provide recommendations for its continuous improvement. Must be able to work cross functionally as a strong collaborator with ability to partner with internal and external stakeholders across multiple global regions. Experience with managing Product Quality Complaints and Pharmacovigilance Quality is a plus Experience in rare disease and/or biologics, a plus.

Knowledge, Skills and Abilities:

Extensive hands-on experience in product lifecycle management including late-phase innovative drug development, medical device, combination product and global commercial launch with global CMC regulatory filings (IND/IMPD/CTA/NDA/BLA/MAA, etc.) in a multinational pharmaceutical organization. Demonstrate project and cross-functional team leadership, as well as people management skills across different cultures. Thorough understanding and working experience in innovative drug development and manufacturing of drugs and biologics concerning GMP operations, quality systems, ICH guidelines, FDA, EMA, and associated international regulatory requirements. Extensive working experience with management and oversight of the analytical activities at CDMOs or CTLs with quality mind-set and leadership. Strong analytical and problem-solving skills with strategic and sound technically driven decision-making ability. Highly effective and strong ability to influence and lead cross-functional teams. Strong sense of ethics and honesty. Ability to communicate with all levels of management and peers within the organization. Effective written and verbal communication skills and interpersonal skills. The salary range for this position is $320,000 to $340,000 USD. Compensation will be determined based on several factors including, but not limited to; skill set, years of experience, and the employee's geographic location. Please note that the required compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits unless otherwise provided. #

LI-HYBRID

Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran's status or any other classification protected by applicable State/Federal/Local laws. 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