Principal Scientist Lead Discovery and Targeted Protein Degradation Biochemistry Employer Amgen Location Thousand Oaks, California Start date Aug 4, 2026 View more categories View less categories Discipline Science/R D , Biotechnology Required Education Bachelors Degree Position Type Full time Hotbed Biotech Beach , Best Places to Work Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Company Job Details Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist Lead Discovery and Targeted Protein Degradation Biochemistry What you will do Lets do this. Lets change the world. In this role, you will lead protein reagent generation and biochemical assay development to support challenging drug discovery campaigns, including induced proximity and targeted protein degradation (TPD) programs. We are seeking an exceptional scientist with deep expertise in protein biochemistry and mechanistic assay development. The successful candidate will lead a small team and provide scientific leadership across drug discovery programs from hit identification through validation and optimization. Within LD-TPD, this role will develop and execute strategies for protein production, biochemical and biophysical assay development, and mechanistic characterization to support the discovery and advancement of novel small-molecule therapeutics.

The successful candidate will:

Lead protein expression, purification, and characterization strategies for challenging proteins to enable the discovery of novel small-molecule therapeutics. Develop and implement biochemical and biophysical assays to support hit identification, validation, optimization, and mechanism-of-action studies. Serve as a key scientific partner to cross-functional discovery teams, providing technical expertise across a growing portfolio of small-molecule therapeutics. Lead and develop a small team of scientists, providing scientific direction and mentorship. Contribute to scientific strategy and communicate findings to project teams and leadership as appropriate. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The successful professional we seek is an exceptional scientist with these qualifications.

Basic Qualifications:

Doctorate degree (PhD) in Biochemistry, Chemical Biology, Structural Biology, Protein Engineering or a related field and 2 years of relevant industry experience in drug discovery OR Masters degree and 5 years of relevant industry experience in drug discovery OR Bachelors degree and 7 years of relevant industry experience in drug discovery

Preferred Qualifications:

Proven expertise in protein purification and biochemical assay development for challenging targets. Extensive experience in protein expression across mammalian, insect, and microbial systems. Strong background in biochemical and biophysical approaches to interrogate target engagement, protein-protein interactions, and small molecule mechanism-of-action. Expertise in protein engineering, including construct design, mutagenesis, and expression optimization to support biochemical and structural studies. Hands-on experience developing and optimizing biochemical and biophysical assays, including TR-FRET/HTRF, fluorescence polarization (FP), AlphaLISA, and BLI/SPR-based approaches. Familiarity with targeted protein degradation (TPD) and induced proximity modalities. Track record of effective collaboration within cross-functional discovery teams and managing priorities across multiple discovery programs. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Company We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world's leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide. We live the mission. We win together. We thrive on continual challenge. Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission. At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we're transforming the promise of science and biotechnology into therapies that have the power to restore health. Connect with us to explore how you can Win, Live, and Thrive at Amgen.

Company info Website http:

//careers.amgen.com/ Phone 805-447-1000 Location Corporate Headquarters One Amgen Center Drive Thousand Oaks California 91320-1799 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert Similar jobs Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs Thousand Oaks, California Scientist II /Sr Scientist I , Analytical R D North Chicago, IL Advisor - In Vivo CAR Discovery Boston, Massachusetts