Title:

Research Associate, RNAi Chemical Development

DURATION

1+ year with the potential to extend (up to 2-year max)

LOCATION

Boulder, CO

• ONSITE

SCHEDULE

8am-5pm (some flexibility)

MUST HAVES

Science/engineering degree (AS, BS, BA degree) Excitement for the role and willing personality Team mentality and strong communication skills PURPOSE This role supports delivery of high-quality oligonucleotide starting materials to innovation and process development teams, enabling ligation-based RNAi manufacturing development and platform expansion. The position is responsible for maintaining a reliable supply system to support fast-paced program advancement.

RELATIONSHIPS

Collaborates with RNAi Chemical Development, Innovation, and Scale-Up teams. Interfaces with API development and oligonucleotide production stakeholders. Individual contributor within a cross-functional environment.

ESSENTIAL FUNCTIONS

Support preparation and delivery of oligonucleotide starting materials. Execute laboratory procedures related to oligonucleotide synthesis, processing, and purification. Operate and maintain workflows ensuring reliable material supply. Support ligation development through timely substrate preparation. Maintain equipment and document workflows and materials. Drive continuous improvement in efficiency and scalability.

QUALIFICATIONS

Education:

Bachelor's or Master's in chemistry, biochemistry, or related field.

Experience:

0-3+ years of relevant lab experience.

Technical Skills:

• Familiarity with standard laboratory techniques.
• Experience with HPLC or LC-MS is a plus.
• Familiarity with automated oligonucleotide synthesizers (e.g., Mermade systems) is preferred.
• Experience with ion-exchange purification methods for oligonucleotides is preferred.
• Basic understanding of RNAi or oligonucleotide chemistry preferred.