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Quarry Thera Operations, Inc
Principal Scientist, DEL Selections
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What they do
A Biophysicist is a scientist who uses physics to study biological systems using an interdisciplinary approach. Studies from molecules to organisms are conducted, analyzed, and interpreted for scientific evidence in proving or providing information for the greater good of medicine or science. May determine the effects of foods, drugs, serums, hormones, and other substances on tissues and vital processes of living organisms.
$117,216 / year median in Connecticut
+10% projected growth
Job Description
Principal Scientist, DEL Selections Quarry Thera Operations, Inc New Haven, CT Job Details Full-time 1 day ago Benefits Free parking Disability insurance Relocation assistance Health insurance Dental insurance 401(k) Paid time off Vision insurance Qualifications Sample preparation Full Job Description Principal Scientist, DEL Selections Quarry Thera Quarry Thera is a New Haven CT based, venture-backed biotechnology company focused on the development of novel induced proximity approaches to address clinical unmet need across therapeutic areas. Quarry was co-founded by Yale Professor Craig Crews and ex-Pfizer leader Mikael Dolsten, and has a leadership team with deep expertise in molecular glue and bifunctional small molecule drugs, platform innovation, and company building. Quarry is funded by top-tier venture firms. Position Summary We have an exciting opportunity for an experienced, highly motivated and independent scientist to join our team. This position offers a strategic and hands-on opportunity to contribute to multiple preclinical programs and the development of proximity-inducing small molecule drugs. The candidate will work closely with multidisciplinary teams, present findings to the leadership team, and make a meaningful impact on the company's portfolio and on patient health. The ideal candidate will bring hands-on expertise in DNA-encoded library screening and demonstrate dedication and urgency in a fast-moving biotech environment. This position reports to the Associate Director, Biophysics and will be located in New Haven, CT. Principal Responsibilities Key responsibilities of this role include, but are not limited to:
- Leverage expertise in DEL selections to discover and validate molecular glues through protein capture assays, selection workflows, and biophysical assays
- Set up the lab for internal DEL selections from reagent validation through NGS sample preparation
- Collaborate with biology, chemistry and computational team members to build mechanistically driven selection strategies
- Coordinate with key stakeholders on DEL data processing and analysis
- Communicate strategy and key findings cross-functionally to drive projects from hit identification into hit-to-lead
- Evaluate new assay technologies (SPR, TR-FRET, etc.) in support of compound characterization Qualifications
- PhD/Postdoc with 3-5 years experience or BS/MS with 15-20 years experience
- Deep knowledge of DEL selections, sample preparation, and data processing
- Ability to work independently and drive multiple, simultaneous screening campaigns
- Understanding of best practices in hit identification and validation with an enthusiasm to participate beyond the hit discovery phase
- Previous biophysical or biochemical assay experience is a plus
- This role includes laboratory-based work so being on-site in New Haven, CT full-time is required
- Candidates must have current authorization to work in the United States Compensation Quarry offers a competitive compensation package including equity awards and annual bonus.