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Job Function:

Discovery & Pre-Clinical/Clinical Development Job Sub Function:

Biotherapeutics R D Job Category:

Scientific/Technology All Job Posting Locations:

Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of America Job Description:

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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//www.jnj.com/innovative-medicine We are searching for the best talent for a Senior Principal Scientist, Biologics Discovery Process Research (BDPR) Integrator to be located in Spring House, PA or Malvern, PA.

Purpose:

The Senior Principal Scientist, will serve as the scientific and strategic connection point between Therapeutic Development & Supply (TDS) and Discovery teams, enabling seamless end‑to‑end decision‑making for biologics programs. This role is deeply technical and focuses on proactively identifying and mitigating development risks during the discovery phase. The leader will ensure that structural, biophysical, expression, and developability insights are assessed and effectively integrated into Chemistry, Manufacturing and Controls (CMC) strategies and program planning. Additionally, the leader will be tasked with identifying early opportunities to assess knowledge gaps to derisk program development. The preferred candidate brings deep scientific expertise in protein structure and developability, strong understanding of CMC development requirements, and a proven ability to influence without authority while navigating complex cross‑functional environments.

You will be responsible for:

• Serving as the BDPR integrator on Discovery project teams, aligning strategy, data expectations, and technical risk assessment across Discovery and Development.

• Providing deep scientific guidance on molecule selection, engineering, developabili...