Research Fellow - PhD Seattle Children's Hospital - 3.8 Seattle, WA Job Details $80,172 a year 4 hours ago Benefits Health insurance Dental insurance Tuition reimbursement Paid time off Vision insurance 403(b) Life insurance Qualifications Doctor of Medicine Immunological assays Cell line culture Data analysis reporting Research proposal writing Research manuscripts Immunological laboratory techniques Flow cytometers Cell Biology Research project design Microbiology Biochemical laboratory techniques Doctor of Philosophy Doctorate in microbiology Cell imaging Experimental design Doctor of Veterinary Medicine Senior level Research findings presentation Cytometry Infectious disease research experience Full Job Description The Acharya laboratory at Seattle Children's Research Institute (www.seattlechildrens.org/directory/mridu-acharya) is seeking a highly motivated postdoctoral scientist to investigate how signaling and intracellular trafficking mechanisms within B cells shape immune responses in infection and autoimmunity. A primary focus of this position will be examining the generation, localization, and function of lung-resident germinal-center and memory B cell responses following influenza infection in mice. The candidate will also have opportunities to investigate how mouse and human B cells process and present different classes of antigens to T cells, using cell-culture and microscopy-based approaches. Together, these projects provide an opportunity to connect the cellular mechanisms operating within B cells with their effects on tissue-level immune responses. Experience in using microscopy to study intracellular localization of proteins or using biochemical approaches to study cell biology would be highly preferred. The successful candidate will work closely with the principal investigator to develop research questions, design and perform experiments, and prepare findings for publication and presentation. The laboratory provides a collaborative and supportive training environment to develop expertise in mucosal immunology, B cell biology, respiratory infection, antigen presentation, and cellular imaging.

KEY RESPONSIBILITIES

Design and perform experiments investigating lung-resident B cell responses following influenza infection in mice. Analyze immune-cell populations from lung and lymphoid tissues using multiparameter flow cytometry. Evaluate antigen-specific B-cell and antibody responses. Contribute to studies of antigen processing, intracellular antigen trafficking, and B cell antigen presentation. Analyze data and contribute to presentations, manuscripts, and research proposals. Participate in the maintenance and experimental use of mouse colonies relevant to the research program. Required Education and Experience Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program. Experience using basic research techniques of specialty area. Required Credentials N/A. Preferred Research experience in immunology, infectious disease, B cell biology, or a related area. Experience with flow cytometry, mammalian cell culture, or mouse models. Ability to design experiments, analyze data critically, and communicate findings clearly. PhD in immunology, microbiology, cell biology, or a related discipline. Compensation Range $80,172 per year Salary Information This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided. Disclaimer for Out of State Applicants This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors . Benefits Information Seattle Children's offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits. About Us Hope. Care. Cure. These three simple words capture what we do at Seattle Children's - to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #

HOPECARECURE

Our founding promise to the community is as valid today as it was over a century ago: we will care for all children in our region, regardless of the families' ability to pay. Together, we deliver superior patient care, advance new discoveries and treatments through pediatric research, and serve as the pediatric and adolescent, academic medical center for Washington, Alaska, Montana and Idaho - the largest region of any children's hospital in the country. U.S. News & World Report consistently ranks Seattle Children's among the nation's best children's hospitals. For more than a decade, Seattle Children's has been nationally recognized in key specialty areas. We are honored to be one of the nation's very best places to care for children and the top-ranked pediatric hospital in Washington and the Pacific Northwest. As a Magnet designated institution, we recognize the importance of hiring and developing great talent to provide best-in-class care to the patients and families we serve. Our organizational DNA takes form in our core values: Compassion, Excellence, Integrity, Collaboration, Equity and Innovation. Whether it's delivering frontline care to our patients in a kind and caring manner, practicing the highest standards of quality and safety, or being relentlessly curious as we work towards eradicating childhood diseases, these values are the fabric of our culture and community. The future starts here. Our Commitment Seattle Children's welcomes people of all experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our patients and families. Our organization recruits, employs, trains, compensates, and promotes based on merit without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics. The people who work at Seattle Children's are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves. Seattle Children's is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.