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Jobs Scientist Emp Type:

Contract South San Francisco, CA, US Wednesday, Sep 16, 2026

Salary :

45.71 - 57.14

Hourly Job Summary:

Seeking Scientist to engineer and generate complex DNA vector constructs for expressing antibodies and novel protein formats.

Description:

The Cell Line Development Group in South San Francisco, CA is seeking a Scientist I/II to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our cancer pipeline candidates.

CHO Cell Line Development & Execution:

Lead the end-to-end execution of CHO cell line development workflows for both pipeline and innovation projects. This includes managing post-transfection selective pressures, high-throughput screening, and scaling cultures from 96-well plates to shake flasks.

Monoclonal Cell Line Generation & Banking:

Expertly perform single-cell cloning to generate and establish monoclonal CHO cell lines. Create, expand, and meticulously characterize master and working cell banks.

Genetic & Molecular Characterization:

Engineer and generate complex DNA vector constructs for expressing antibodies and novel protein formats. Perform deep genetic characterization of cell banks by extracting DNA/RNA for analysis via PCR, qPCR/ddPCR, and Next-Generation Sequencing (NGS).

Advanced Instrumentation & Automation:

Skillfully operate and maintain a suite of key laboratory instruments, including ViCell, Octet, flow cytometers, ambr15, HPLC, and automated imagers.

Cross-Functional Collaboration & Communication:

Present scientific updates at cross-functional meetings, collaborating closely with colleagues in purification, analytical, and formulation development to drive projects forward and meet aggressive timelines.

Data Integrity & Documentation:

Maintain meticulous, contemporaneous records of all experimental designs, data, and analysis in electronic lab notebooks (ELNs), ensuring compliance with standards for data integrity and good documentation practices.

Qualifications:

3-5 years of experience CHO cell line development Flow cytometry

California Fair Chance Act:

Synectics Inc. will consider qualified applicants with a criminal history pursuant to the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if Synectics Inc. is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. Find out more about the Fair Chance Act by visiting calcivilrights.ca.gov/fair-chance-act/.

Benefits:

Healthcare Insurance:

Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance:

Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance:

Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. 401(k)

Plan:

The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins. Synectics is an equal opportunity employer.