at Adecco US, Inc. in Rockford, Illinois, United States Job Description

SCIENTIST III - ORGANIC CHEMISTRY / FATTY ACID SYNTHESIS & PROCESS DEVELOPMENT

Location:

Rockford, IL Compensation:

$ 50.00/hour

Function:

R D / Organic Chemistry /

Process Development Project:

Fatty Acid Synthesis Number of Openings:

2

Direct Reports:

0

Shift:

Day Relocation:

Not approved

Employment Type:

Contract / Project-Based

POSITION SUMMARY

The Scientist III will play a critical role in the Fatty Acid Synthesis and Process Development project , developing, optimizing, scaling, and documenting synthetic and purification processes for priority lipid and fatty-acid-related raw materials used to support cell-culture media production. The Scientist III will apply advanced expertise in organic synthesis, bio-organic chemistry, lipid chemistry, purification, process development, and analytical characterization to establish robust and reproducible processes that meet internal raw-material specifications and are suitable for scale-up and transfer to manufacturing operations. The ideal candidate will hold a Ph.D. in Organic Chemistry, Bio-Organic Chemistry, or a closely related discipline and have strong hands-on experience with organic synthesis. Experience in bioanalytical characterization and analytical interpretation is highly desirable.

KEY RESPONSIBILITIES

+ Design, plan, and independently execute laboratory experiments for the synthesis and process development of fatty acids, glycerides, phospholipids, and related lipid molecules.

+ Develop and optimize synthetic routes for priority materials, with emphasis on yield, purity, reproducibility, scalability, safety, and raw-material availability.

+ Perform multi-step organic synthesis and reaction optimization to address challenging synthetic targets and process-development needs.

+ Develop and optimize purification strategies using normal-phase and reverse-phase chromatography, preparative HPLC , flash chromatography, crystallization, extraction, precipitation, and other appropriate techniques.

+ Characterize starting materials, intermediates, impurities, and final products using HPLC , LC-MS/MS or

MS, NMR , FT-IR, UV/ VIS , ELSD / CAD

, and other applicable analytical techniques.

+ Interpret analytical data to monitor reactions, confirm identity, assess purity, investigate impurities, and troubleshoot process issues.

+ Investigate impurity profiles and troubleshoot synthesis, purification, stability, and recovery issues that could prevent materials from meeting internal specifications.

+ Conduct feasibility studies using lower-purity or alternate-source starting materials and establish process conditions necessary to achieve target product quality.

+ Support scale-up from laboratory development to gram and hundreds-of-gram quantities.

+ Develop processes suitable for transfer from R D to Rockford manufacturing operations.

+ Partner with Analytical Development to establish or refine analytical methods for purity, identity, and process-development decision-making.

+ Prepare materials for internal evaluation, packaging/formulation activities, process validation, and manufacturing transfer as required.

+ Prepare experimental protocols, development reports, batch/process instructions, technical summaries, and documentation supporting testing, validation, and production.

+ Maintain complete and accurate laboratory records, including experimental conditions, calculations, raw data, observations, deviations, results, and conclusions.

+ Work cross-functionally with R D, Analytical Development, Operations, Quality, Procurement/Sourcing, and Project Management teams.

+ Communicate technical results, project status, technical risks, recommendations, and mitigation strategies to project stakeholders.

+ Follow departmental quality systems, chemical hygiene requirements, EHS procedures, and safe laboratory practices.

REQUIRED QUALIFICATIONS

+ Ph.D. in Organic Chemistry, Bio-Organic Chemistry, Medicinal Chemistry, Chemical Sciences, or a closely related scientific discipline.

+ Strong hands-on experience with organic synthesis , including multi-step synthesis and reaction optimization.

+ Demonstrated ability to independently plan and execute synthetic chemistry experiments.

+ Experience developing and optimizing purification processes for complex organic molecules.

+ Hands-on experience with preparative purification techniques, including chromatography and related methods.

+ Strong ability to interpret HPLC , LC-MS/MS or MS, NMR , and FT-IR data.

+ Experience using analytical data for reaction monitoring, identity confirmation, purity assessment, and impurity troubleshooting.

+ Ability to independently troubleshoot synthetic and purification challenges and design experiments to resolve technical problems.

+ Experience documenting laboratory work in a manner appropriate for process development, technical transfer, and quality-controlled environments.

+ Ability to work independently while collaborating effectively within a cross-functional R D environment.

+ Strong written, verbal, technical, and data-presentation skills.

PREFERRED QUALIFICATIONS

+ Industrial experience in lipid chemistry, fatty-acid chemistry, bio-organic chemistry, glycerides, phospholipids, surfactants, or related molecules .

+ Experience synthesizing or purifying phosphatidylcholines, diacylglycerols, or structurally related lipid molecules.

+ Bioanalytical experience involving characterization of organic or lipid-based compounds.

+ Hands-on experience with Biotage Isolera, Biotage Selekt , or comparable flash/preparative chromatography systems.

+ Experience with CAD or ELSD detection for lipid and non-chromophoric compounds.

+ Experience scaling synthetic chemistry processes from small-scale feasibility studies to gram or hundreds-of-gram quantities.

+ Experience with reagent/raw-material product development, process validation, change control, or transfer of R D processes to manufacturing.

+ Working knowledge of raw-material specifications, supplier qualification, and technical evaluation of alternate-source materials.

+ Experience working in regulated, quality-controlled, or GMP -related laboratory environments.

EDUCATION

Required:

Ph.D. in Organic Chemistry, Bio-Organic Chemistry, Medicinal Chemistry, Chemical Sciences, or a closely related scientific discipline.

Additional consideration:

Candidates with an M.S. or Bachelor's degree may be considered when accompanied by substantial, directly relevant industrial synthetic chemistry experience.

Core educational requirement:

Ph.D.-level expertise in Organic Chemistry, Bio-Organic Chemistry, or a related discipline , with demonstrated hands-on organic synthesis experience.

CORE TECHNICAL COMPETENCIES

+ Organic Synthesis

+ Multi-Step Synthesis

+ Reaction Optimization

+ Bio-Organic Chemistry

+ Lipid & Fatty-Acid Chemistry

+ Process Development

+ Scale-Up Chemistry

+ Purification & Chromatography

+ Preparative HPLC

+ Flash Chromatography

+ HPLC

+ LC-MS/MS / Mass Spectrometry

+ NMR

+ FT-IR

+ ELSD / CAD

+ Impurity Investigation

+ Analytical Data Interpretation

+ Technical Documentation

+ Process Transfer

+ Cross-Functional R D Collaboration

SUCCESS MEASURES

+ Project development milestones are completed according to the established project plan.

+ Target materials consistently meet required identity, purity, and quality specifications.

+ Developed processes demonstrate acceptable yield, reproducibility, scalability, and operational practicality.

+ Technical risks, deviations, and process challenges are identified early and investigated using sound scientific methodology.

+ Clear mitigation strategies To view full details and how to apply, please login or create a Job Seeker account