Scientist Employer Intellia Therapeutics Location Cambridge, MA Start date Sep 8, 2026 View more categories View less categories Discipline Science/R D , Biotechnology Required Education Bachelors Degree Position Type Full time Hotbed Genetown , Best Places to Work Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Company Job Details Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We wantall ofour people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How You Will Achieve More:

We are seeking a Scientist to join our Translational Medicine group, focused on discovery proteomics to identify and characterize biomarkers and profile immune recognition of therapeutic candidates. The ideal candidate will bring hands-on mass spectrometry expertise across biomarker discovery workflows and immunopeptidomics, with experience in top-down or native protein mass spectrometry considered a strong plus. This is a hands-on, laboratory-based role where your data will directly inform how we evaluate and advance our therapeutic candidates.

Responsibility:

Design and execute discovery proteomics workflows — including sample preparation, LC-MS/MS data acquisition, and downstream bioinformatic analysis — to identify and characterize candidate biomarkers across biological matrices. Develop and run immunopeptidomics workflows, from MHC class I/II immunoaffinity purification through peptide elution, cleanup, and nanoflow LC-MS/MS, to profile HLA-presented peptides and characterize immune recognition of therapeutic candidates. Analyze complex proteomics and immunopeptidomics datasets using specialized search software and bioinformatic tools, translating results into clear, actionable insights. Apply top-down and/or native mass spectrometry approaches, where relevant, to characterize protein higher-order structure, complex integrity, and post-translational modifications (a valued but not required skill set). Select and optimize separation chemistry and MS platforms best suited to each analyte and biological question. Plan and lead well-defined assay development and discovery projects end-to-end, independently identifying the broader objectives each project should address. Author assay methods, SOPs, and bioanalytical/risk assessment reports, and partner closely with immunology, process development, and other cross-functional teams to communicate findings.

About You:

Hands-on experience with immunopeptidomics workflows, including MHC/HLA immunoprecipitation and low-abundance peptide

LC-MS/MS

Experience with native and/or intact protein mass spectrometry Familiarity with HLA-binding prediction tools and immunopeptidomics-specific proteomics search software Strong bioanalytical and structural mass spectrometry background Strong problem-solving skills, with the ability to apply in-depth theoretical knowledge to complex technical challenges within a defined scientific area Ability to execute studies, manage outlined timelines, and ensure data quality Ability to draw conclusions from experimental results and apply them to new experiments Excellent organizational, written, and verbal communication skills Strong interpersonal skills and the ability to prioritize effectively across competing demands Comfortable operating in a fast-paced, deadline-driven environment PhD in a biological or relevant technical/engineering field, or equivalent through a combination of education and experience 0-3+ years of relevant experience post-PhD (or 6-9+ years with an MS, or 8-11+ years with a BS) Must be able to lift up to 15 pounds at times. Prolonged periods of sitting at a desk and working on a computer. #

LI-Onsite EEOC Statement:

Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $123,300.00 - $150,700.00 USD per year. The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company's discretion. For more information about Intellia's benefits, please click here . Company Many of us pursuing work in the biotechnology industry are inspired by a loved one who is living with a disease or the loss of someone in our community. Rare genetic and oncological and immunological diseases not only affect the people living with often debilitating and life-threatening symptoms, but these disorders also significantly impact their families, friends and caregivers. Our researchers work tirelessly to harness the genome editing technology CRISPR/Cas9 for human therapeutic use. Jennifer Doudna, an Intellia co-founder, and Emmanuelle Charpentier were awarded the 2020 Nobel Prize in Chemistry for their pioneering work in CRISPR. We at Intellia are humbled to have a hand in making what we believe to be medical history. As a leader in this space, we take this responsibility to patients seriously. We are employing a modular genome editing platform to create diverse in vivo and ex vivo pipelines, spanning a range of therapeutic indications. Guided by this full-spectrum approach, we are committed to making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to creating novel engineered cell therapies for various cancers and autoimmune diseases. Change life stories with genome editing therapies!

Stock Symbol:

NTLA Company info Website http://intelliatx.com/ Phone (857) 285-6200 Location 40 Erie Street Cambridge Massachusetts 02139 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert Similar jobs Senior Bioinformatics Engineer II Cambridge, Massachusetts Senior Biologist Indianapolis, Indiana Sr. AI Science Lead San Francisco, California