Scientist, Oligonucleotide Drug Substance

Scientist, Oligonucleotide Drug Substance Alnylam Pharmaceuticals paid time off United States, Massachusetts, Cambridge 675 West Kendall Street (Show on map) May 11, 2026

Overview:

The Scientist, Process Sciences will be responsible for development, characterization and scale-up of speciality starting materials used in the Oligo DS manufacture processes. The successful candidate will work closely with internal cross-functional teams and external contract manufacturing organizations (CROs) on process development, process transfer, and oversight of starting materials, conjugates and excepients used in Oligonucleotide drug candidate manufacturing. This position is onsite and will be located at our Kendall Square offices in Cambridge, MA.

Responsibilities:

Contribute to process development, optimization, and scale-up of speciality starting materials Support the process and product characterization of small molecules and oligonucleotide APIs Contribute to the management and optimization of in-house and contract manufacturing processes Author and review technical protocols and development reports in support of manufacturing and process characterization activities for CTA filing Author, edit, and review manufacturing documentation according to regulatory and procedural guidelines Support RA activities with authoring starting materials related Work closely with analytical development, manufacturing technical oparations, QA, QC, supply chain, Regulatory Affairs and CMO/CRO on the process transfer and process optimization Contribute to strategic technical discussions and presenting progress at internal and external scientific meetings

Qualifications:

Ph.D. in chemistry, chemical engineering, or biochemical engineering or

B.S./M.S.

with 7+ years of relevant experience Process research and development experience in organic synthesis Demonstrated proficiency in the design and development of practical processes for manufacture of small molecules, peptides and oligonucleotides Hands-on experience in process development and analytical methods for process and product characterization Excellent interpersonnel, organizational and communication skills Demonstrated strong operational execution and problem-solving skills Desire to work in a fast-paced, deadline-driven work environment #LI-KB1 #LI-Onsite U.S. Pay Range $117,000.00 - $158,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. >