Oligonucleotide Synthesis Scientist Quintara Biosciences - 3.0 Watertown, MA Job Details Full-time From $80,000 a year 18 hours ago Qualifications Equipment setup (production tasks) Chemical Engineering Automation Procedural guides Workflow management (operations management method) Technical documentation Laboratory instruction Granulation in formulation development Leading laboratory workflow efficiency optimizations Technical writing experience within manufacturing Engineering process optimization Chemical synthesis Equipment troubleshooting Molecular biology techniques Implementing laboratory quality control protocols Manufacturing standard operating procedures Data integrity and documentation Biochemical laboratory techniques Policy & process development Bachelor's degree Laboratory standard operating procedures Quality improvement Compliance documentation Laboratory preventive maintenance Organizational skills Chemistry Technical skills instruction Technical troubleshooting support Process improvement planning Handling nucleic acids Full Job Description Take a Look at Your Future with Quintara Biosciences The mission of Quintara Biosciences is to provide integrated DNA services (DNA reading, writing, editing, and making) to the life science community by creating and delivering innovative transitional technologies and platforms. A path towards your most rewarding career. You will be challenged to work in a results-driven, fast-paced organization; you will work with passionate professionals who strive to develop innovative products and technologies that advance the life sciences; and you will excel in an environment of respect, integrity, and fair opportunities for growth.

POSITION SUMMARY

The Oligo Synthesis Chemist is responsible for the production, optimization, and quality of synthetic oligonucleotides using automated DNA synthesizers. This role involves executing synthesis workflows, troubleshooting production issues, maintaining laboratory equipment, documenting manufacturing activities, and supporting continuous process improvement. The successful candidate will work closely with cross-functional teams to ensure high-quality products and efficient laboratory operations.

PRIMARY RESPONSIBILITIES

： Perform routine oligonucleotide synthesis using automated DNA synthesizers in accordance with established SOPs. Execute downstream processing, including deprotection, purification, desalting, quantification, and quality control of synthesized oligonucleotides. Ensure all production activities comply with laboratory quality standards and established operating procedures. Maintain accurate and complete laboratory documentation, including batch records, production logs, and experimental data. Monitor synthesis performance and investigate production deviations or quality issues. Assist in root cause analysis and implement corrective and preventive actions (CAPA). Perform routine maintenance, calibration, and basic troubleshooting of oligonucleotide synthesizers and other laboratory equipment. Assist in process optimization and technology improvements to enhance synthesis efficiency, product quality, and laboratory productivity. Collaborate with Manufacturing, Quality Control, Sequencing, and Gene Synthesis teams to support production schedules and customer requirements. Maintain laboratory cleanliness, safety, and compliance with company policies and regulatory requirements. Perform other duties as assigned.

EDUCATION

： Bachelor's degree or higher in Chemistry, Biochemistry, Molecular Biology, Biotechnology, Chemical Engineering, or a related scientific discipline.

PREFERRED EXPERIENCE

： Demonstrated experience establishing or scaling an oligonucleotide synthesis laboratory or manufacturing operation from the ground up is strongly preferred. Experience developing, implementing, and optimizing oligonucleotide synthesis workflows in a production environment. Experience writing, validating, and maintaining SOPs, work instructions, and production documentation. Experience with automated oligonucleotide synthesis or nucleic acid manufacturing is required. Experience with

HPLC, LC-MS, UV

spectrophotometry, or other analytical techniques. Experience working in a GLP- or ISO-compliant laboratory environment is preferred.

SKILL REQUIREMENTS

： - Required Skills Extensive knowledge of phosphoramidite-based oligonucleotide synthesis chemistry and automated synthesizer operation. Proven hands-on experience independently performing the complete oligonucleotide production workflow, including synthesis, cleavage/deprotection, purification, QC, troubleshooting, and release. Demonstrated ability to establish new laboratory workflows, optimize production processes, and implement best practices for routine manufacturing. Experience developing, writing, and training personnel on SOPs, work instructions, and laboratory documentation. Ability to install, qualify, maintain, and troubleshoot production equipment. Experience transferring manufacturing processes and training technical staff through hands-on instruction. Strong documentation and record-keeping skills. - Competencies Proven ability to build and implement new laboratory operations with minimal supervision. Strong process development and continuous improvement mindset. Excellent troubleshooting and root-cause analysis skills. Ability to mentor and provide hands-on training to laboratory staff. Strong leadership, organization, and cross-functional communication skills. Ability to manage multiple priorities in a fast-paced manufacturing environment

WORKING RELATIONSHIPS

Report to: Production Manager Works with: you will be working with internal oligo team, as well as downstream gene synthesis, molecular cloning and NGS team and so on

Job Type:

Full-time Pay:

From $80,000.00 per year Shift availability: Day Shift (Preferred)

Work Location:

In person