Research Associate II ~ Bioanalytical/In Vitro

ADME/DMPK

Employer Nurix Therapeutics Location Brisbane, CA Start date Aug 7, 2026 View more categories View less categories Discipline Regulatory , Science/R D , Research , Pharmacokinetics Required Education Bachelors Degree Position Type Full time Hotbed Biotech Bay Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Company Job Details Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Nurix Therapeutics is searching for a motivated Research Associate II to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques. Responsibilities Provide bioanalytical support for in-house PK, non-GLP safety TK Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis Independently develop

LC-MS/MS

methods to quantitate small molecules in in vitro and in vivo samples Conduct in-vitro stability assays to understand metabolism of drugs Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment Independently operate, troubleshoot and maintain

LC-MS/MS

systems Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines Maintain accurate and detailed scientific electronic laboratory notebooks Perform all duties in keeping with the Company's core values, policies and all applicable regulations Preferred Qualifications & Experience Experience with H/UPLC and mass spectrometry Good working knowledge of

SCIEX LC-MS/MS

systems for small molecule quantitation PK analysis using Phoenix or other data management software Management experience with CROs for outsourcing BA activities is preferred Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports. Excellent oral and written communication skills Minimum Requirements BS or master's with 4 years' experience working in a discovery setting using

LC-MS/MS

within a pharmaceutical/biotechnology company Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using

LC-MS/MS

Experience with

AB SCIEX

mass spectrometry software Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment Fit with Nurix Culture and Values Strong team orientation; highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view Location Brisbane, CA - Onsite Salary Range 93K - 107K Company Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info Website https:

//www.nurixtx.com/ Phone 415-660-5320 Location 1700 Owens Street Suite 205 San Francisco California 94158 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert Similar jobs (Fixed Term) Scientist, Immunogenicity, Bioanalytical and Molecular Assays Oxford - England Sr. Scientist- PKDM-BA (Immunoassay) Thousand Oaks, California Sr. Specialist, Bioanalytics Cambridge, Massachusetts