Oligonucleotide Scientist II#26-02251

$36.97-$49.65 per hour

South San Francisco, CA

Onsite Job Description Position:

Oligonucleotide Scientist II

Location:

1 DNA Way, South San Francisco, CA 94080

Job Type:

4-Month Contract (Potential for Extension or Full-Time Conversion)

Pay Rate:

$36.97 - $49.65 /hour (W2)

Benefits:

Weekly Pay, Medical, Dental, and Vision Insurance Work Schedule Work Model:

100% On-site (South San Francisco, CA)

Schedule:

Monday through Friday

Shift:

Standard 8-hour day shift Interview Process

One Round (30 Minutes)

Local candidates are expected to attend the interview on-site.

Candidates outside the immediate area may interview virtually. About the Role

Our client is seeking a Scientist II to join the Nucleic Acid Design and Discovery (NADD) team within the Protein Sciences (PS) department. This role is ideal for a creative, collaborative, and self-driven scientist with hands-on experience in oligonucleotide synthesis and discovery.

You will contribute to the development of next-generation oligonucleotide therapeutics, working closely with multidisciplinary teams across neuroscience, immunology, and oncology research. Experience with RNAi therapeutics, oligonucleotide delivery, or large molecule drug discovery is highly desirable. Key Responsibilities

Conduct research in oligonucleotide therapeutic drug discovery to support innovative treatment strategies.

Perform hands-on oligonucleotide synthesis using automated synthesizers.

Troubleshoot synthesis processes and support impurity profiling.

Purify and characterize oligonucleotides using HPLC, mass spectrometry, and related analytical techniques.

Operate and maintain laboratory equipment, including oligonucleotide synthesizers, HPLC systems, and desalting units.

Review scientific literature and design nucleic acid chemistry strategies.

Collaborate with cross-functional chemistry and biology teams to advance therapeutic candidates.

Develop and optimize scaled-up synthesis methods for lead compounds.

Coordinate material production for preclinical studies.

Maintain high laboratory productivity to meet project timelines for in vitro and in vivo research. Required Qualifications

Bachelor's or Master's degree in Organic Chemistry or a related scientific discipline.

Hands-on experience with:

Automated oligonucleotide synthesizers

Oligonucleotide synthesis and purification

HPLC analysis

Mass spectrometry characterization

Experience with Client nucleic acid chemistry.

Strong analytical, troubleshooting, and laboratory skills.

Excellent communication, collaboration, and organizational abilities.

Ability to work effectively in a fast-paced, interdisciplinary research environment. Preferred Qualifications

Pharmaceutical or biotechnology industry experience in RNAi therapeutic research and development.

Knowledge of:

Nucleic acid therapeutic modalities

Modification chemistries

Sequence selection strategies

Mechanisms of action

Experience with:

Oligonucleotide therapeutics

Large molecule drug discovery

Oligonucleotide delivery technologies

Bioconjugation #TMRD