Scientist, Peptide Chemistry

New Scientist, Peptide Chemistry South San Francisco, CA Apply Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description :

We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico's proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR). By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine.

Key Responsibilities:

Drive Discovery:

Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies

Innovate Synthetic Workflows:

Onboard and optimize novel chemistries for high-throughput, automated peptide synthesis; troubleshoot complex synthetic challenges to generate high-quality leads, and curate a custom library of building blocks

Cross-Functional Partnership:

Collaborate with biology, software, automation, assay, and pharmacology teams to ensure seamless execution of ML platform objectives and drug discovery milestones

Mentorship and Management:

Actively mentor junior scientists, fostering a culture of technical excellence, continuous learning, and collaborative innovation Manage external collaborations and CROs efficiently, including teams of chemists, DMPK scientists and formulation experts

Position Requirements :

Ph.D. in Organic Chemistry, Peptide Chemistry, or a related discipline with 0-2 years of industry experience in drug discovery Experience in peptide hit discovery, SAR campaigns, ADMET optimization, and peptide formulation Proven experience building and interpreting complex assay cascades, including biophysical characterization, functional protein/cell-based assays, and ADMET screening High proficiency in automated synthesis, purification (HPLC, Flash, SPE), and characterization (LCMS, NMR, CD, etc.) Demonstrated ability to implement diverse chemistries, including backbone-modifications, macrocyclization, stapling, and bioconjugation via solid- or solution-phase strategies Excellent problem-solving and analytical skills Exceptional interpersonal and communication skills for effective collaboration across diverse functional groups Must be willing to work onsite 5 days per week Nice to

Have:

Experience with organic synthesis, including transition metal catalysis and synthesis of non-canonical amino acids, is highly desired Experience with automation, software, and data-science integration into chemistry workflows Ability to utilize AI-tools to improve efficiency of research and build programs for data analysis or synthesis Knowledgeable on the key principles of ML-design for peptide therapeutics Prior experience with peptide-specific computational tools for hit discovery, SAR prioritization, molecular modeling, and physicochemical characterization The estimated base salary range for this role is $135,000 - $145,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses. Create a Job Alert Interested in building your career at Calico ? Get future opportunities sent straight to your email. Create alert Apply for this job

• indicates a required field Autofill with MyGreenhouse First Name
• Last Name
• Email
• Phone Country
• Phone
• 244 results found No results found Afghanistan +93 Åland Islands +358 Albania +355 Algeria +213 American Samoa +1 Andorra +376 Angola +244 Anguilla +1 Antigua & Barbuda +1 Argentina +54 Armenia +374 Aruba +297 Ascension Island +247 Australia +61 Austria +43 Azerbaijan +994 Bahamas +1 Bahrain +973 Bangladesh +880 Barbados +1 Belarus +375 Belgium +32 Belize +501 Benin +229 Bermuda +1 Bhutan +975 Bolivia +591 Bosnia & Herzegovina +387 Botswana +267 Brazil +55 British Indian Ocean Territory +246 British Virgin Islands +1 Brunei +673 Bulgaria +359 Burkina Faso +226 Burundi +257 Cambodia +855 Cameroon +237 Canada +1 Cape Verde +238 Caribbean Netherlands +599 Cayman Islands +1 Central African Republic +236 Chad +235 Chile +56 China +86 Christmas Island +61 Cocos (Keeling) Islands +61 Colombia +57 Comoros +269 Congo - Brazzaville +242 Congo - Kinshasa +243 Cook Islands +682 Costa Rica +506 Côte d'Ivoire +225 Croatia +385 Cuba +53 Curaçao +599 Cyprus +357 Czechia +420 Denmark +45 Djibouti +253 Dominica +1 Dominican Republic +1 Ecuador +593 Egypt +20 El Salvador +503 Equatorial Guinea +240 Eritrea +291 Estonia +372 Eswatini +268 Ethiopia +251 Falkland Islands +500 Faroe Islands +298 Fiji +679 Finland +358 France +33 French Guiana +594 French Polynesia +689 Gabon +241 Gambia +220 Georgia +995 Germany +49 Ghana +233 Gibraltar +350 Greece +30 Greenland +299 Grenada +1 Guadeloupe +590 Guam +1 Guatemala +502 Guernsey +44 Guinea +224 Guinea-Bissau +245 Guyana +592 Haiti +509 Honduras +504 Hong Kong SAR China +852 Hungary +36 Iceland +354 India +91 Indonesia +62 Iran +98 Iraq +964 Ireland +353 Isle of Man +44 Israel +972 Italy +39 Jamaica +1 Japan +81 Jersey +44 Jordan +962 Kazakhstan +7 Kenya +254 Kiribati +686 Kosovo +383 Kuwait +965 Kyrgyzstan +996 Laos +856 Latvia +371 Lebanon +961 Lesotho +266 Liberia +231 Libya +218 Liechtenstein +423 Lithuania +370 Luxembourg +352 Macao SAR China +853 Madagascar +261 Malawi +265 Malaysia +60 Maldives +960 Mali +223 Malta +356 Marshall Islands +692 Martinique +596 Mauritania +222 Mauritius +230 Mayotte +262 Mexico +52 Micronesia +691 Moldova +373 Monaco +377 Mongolia +976 Montenegro +382 Montserrat +1 Morocco +212 Mozambique +258 Myanmar (Burma) +95 Namibia +264 Nauru +674 Nepal +977 Netherlands +31 New Caledonia +687 New Zealand +64 Nicaragua +505 Niger +227 Nigeria +234 Niue +683 Norfolk Island +672 North Korea +850 North Macedonia +389 Northern Mariana Islands +1 Norway +47 Oman +968 Pakistan +92 Palau +680 Palestinian Territories +970 Panama +507 Papua New Guinea +675 Paraguay +595 Peru +51 Philippines +63 Poland +48 Portugal +351 Puerto Rico +1 Qatar +974 Réunion +262 Romania +40 Russia +7 Rwanda +250 Samoa +685 San Marino +378 São Tomé & Príncipe +239 Saudi Arabia +966 Senegal +221 Serbia +381 Seychelles +248 Sierra Leone +232 Singapore +65 Sint Maarten +1 Slovakia +421 Slovenia +386 Solomon Islands +677 Somalia +252 South Africa +27 South Korea +82 South Sudan +211 Spain +34 Sri Lanka +94 St.

Barthélemy +590 St. Helena +290 St. Kitts & Nevis +1 St. Lucia +1 St. Martin +590 St. Pierre & Miquelon +508 St. Vincent & Grenadines +1 Sudan +249 Suriname +597 Svalbard & Jan Mayen +47 Sweden +46 Switzerland +41 Syria +963 Taiwan +886 Tajikistan +992 Tanzania +255 Thailand +66 Timor-Leste +670 Togo +228 Tokelau +690 Tonga +676 Trinidad & Tobago +1 Tunisia +216 Turkey +90 Turkmenistan +993 Turks & Caicos Islands +1 Tuvalu +688 U.S. Virgin Islands +1 Uganda +256 Ukraine +380 United Arab Emirates +971 United Kingdom +44 United States +1 Uruguay +598 Uzbekistan +998 Vanuatu +678 Vatican City +39 Venezuela +58 Vietnam +84 Wallis & Futuna +681 Western Sahara +212 Yemen +967 Zambia +260 Zimbabwe +263 Resume/CV

• Attach Attach Dropbox Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Dropbox Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website How did you hear about this job? Are you eligible to work in the United States?
• Select... Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa status)?
• Select... Education - School Attended Highest Degree Earned By clicking 'Submit Application' below, I understand and acknowledge that my Personal Information will be processed by Calico pursuant to the terms of its Worker and Applicant Privacy Notice
• Select.

.. Worker and Applicant Privacy Notice Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Calico 's Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. Gender Select... Are you Hispanic/Latino? Select... Race & Ethnicity Definitions If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Veteran Status Select... Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Why are you being asked to complete this form? We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability? A disability is a condition that substantially limits one or more of your "major life activities." If you have or have ever had such a condition, you are a person with a disability.