A Bioinformatician uses computers and software tools to study biology and biology-related data. Conducts studies and maintains biology data; may develop specialized bioinformatics software. Analysis may be used for product development at a pharmaceutical company, disease research at a hospital or health policy research at a public health organization.
Reporting to the Bioinformatics Senior Principal Investigator, the Bioinformatics Scientist will focus on complex experimental and clinical bioinformatics data sets.
Responsibilities:
Strong background in tissue-based animal model assays, cell-based assays, cell pathway signaling, biochemistry especially as related to biologically dysfunctional systems. Strong background in design and execution of -Omics experiments (bulk, single-cell, spatial transcriptomics, WES, epigenomics, metabolomics, proteomics, etc), demonstrable hands-on experience with experimental sample-to-data workflows for one or more platforms. Experience executing analysis pipelines using R and/or Python with attention to implementing bioinformatics practices for reproducible and modular analysis (markdown documentation, r/v env locks, git). Proficiency in data science skills related to exploratory data analysis, wrangling (knowledge of coding and processes related to key steps - discovery, structuring/transformation, cleaning, enriching/reduction, validating, and publishing), and visualization using R and/or Python. Writing and improving existing code in R and Python for exploratory and validation data analysis of large-scale multi-omics (DNA, RNA, protein) datasets. Experience with processing and organizing large datasets from public repositories using structured queries and wrangling data to be compatible with analytical pipelines in a cloud-based computing environment. Attention to documentation and standards for reproducibility of code and data integrity.
Qualifications:
A Ph.D or equivalent experience in biological or biochemical sciences with strong skills in one or more Omics approaches (transcriptomics, genomics, proteomics) Experience in Data Science, Bioinformatics or related computational disciplines. Experience in working with large omics datasets using R/Python. Strong understanding of cell biology especially with respect to basic biochemistry, cell signaling, cell replication, transcription, translation processes.
About Us:
Celcuity is a publicly traded commercial-stage biotechnology company developing targeted therapies for multiple solid tumor indications. The company's first FDA-approved product is
REVTORPYK
(gedatolisib), targets all class I isoforms of PI3K and the mTOR complexes to comprehensively block the PAM pathway. The PAM pathway is an important signaling pathway involved in many cancers and has historically been challenging to target. A Phase 3 clinical trial, VIKTORIA-1, evaluating gedatolisib in combination with fulvestrant with or without palbociclib in patients with HR+/HER2- locally advanced or metastatic breast cancer ("ABC"), supported FDA approval of
REVTORPYK
for use in patients without a PIK3CA mutation detected. Gedatolisib phase 3 clinical development programs are focused on the treatment of patients with
HR+/HER2- ABC
in the 1L and 2L settings. A Phase 1b/2 clinical trial evaluating gedatolisib in combination with darolutamide in patients with metastatic castration resistant prostate cancer, is on-going. Celcuity is an Equal-Opportunity Employer. Celcuity is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are competitive. For this role, the anticipated base pay range is $110,000 - $120,000 DOE. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate's geography, qualifications, skills, and experience. The successful candidate will be eligible for an annual performance incentive bonus and a new hire equity package. Celcuity also offers various benefits offerings, including, but not limited to, medical, dental, vision insurance, 401(k) match, PTO, and paid holidays. Notice to Recruiters/Staffing Agencies Recruiters and staffing agencies should not contact Celcuity through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees directly. We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file. Celcuity's receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Celcuity and such organization and will be considered unsolicited. Celcuity will not be responsible for related fees.
