We anticipate the application window for this opening will close on - 28 Sep 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life Cardiac Ablation Solutions develops technologies and therapies used to diagnose and treat cardiac arrhythmias. This team partners across systems engineering, product development, field engineering, technical services, marketing, and clinical stakeholders to ensure successful integration of electrophysiology systems within hospital environments and to support product performance throughout the product lifecycle. This position may be based in Mounds View, Minnesota or Newton, Massachusetts and follows an onsite work model with a minimum of four days per week in the office. As a Sr. Principal Systems Engineer, you will provide technical leadership for system integration and refine your systems engineering skills to conduct interface testing, both within the system and during commercial support, as well as integrating the system into Electrophysiology cath lab hospital environments. Primary Responsibilities Participate on cross-functional development teams in the creation of integration, characterization, and troubleshooting testing, training, and guidance documents. Develop expertise in the application of systems engineering principles and identify opportunities for applying systems engineering within work assigned to the team. Support marketing, field engineering, technical services, and training and education in technical questions. Propose and implement changes to improve systems and/or processes. Travel