Arvinas is a biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer PROteolysis TArgeting Chimeras, or PROTACs, that are designed to harness the body's own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. This differentiated approach has enabled Arvinas to build a broad pipeline of investigational therapies across oncology and neurodegenerative diseases, including ARV-102, targeting LRRK2 for neurodegenerative diseases; ARV-806, targeting

KRAS G12D

for mutated cancers, including pancreatic, colorectal, and non-small cell lung cancers; ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle for spinal bulbar muscular atrophy; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer. Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in May 2026 with the first-ever U.S. Food and Drug Administration (FDA) approval of a PROTAC protein degrader therapy. The approval marked a significant advancement for the field and demonstrated the therapeutic potential of targeted protein degradation as a novel treatment modality. This PROTAC has been out-licensed for commercialization and further development. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and mission - to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We're really excited about the work we're doing inside and outside of Arvinas, and think you will be, too. But don't just take our word for it - learn more about life at Arvinas and what employees have to say . Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www.arvinas.com and connect on LinkedIn and X . Position Summary Arvinas is seeking a highly experienced Development Asset Team Leader to apply expert-level knowledge of biology and the biological mechanisms of drug development to lead cross-functional development teams that are accountable, in partnership with the functional leaders on the Asset Team, for the scientific strategy and seamless execution of early oncology development programs across all phases of drug development. The successful candidate will apply deep expertise in biological sciences to recommend and drive the strategy of oncology assets and execution against planned timelines for early, mid-stage and late-stage assets. The Development Asset Team Leader will lead a cross-functional team including clinical research, clinical operations, regulatory affairs, clinical pharmacology, translational/companion diagnostics, CMC, non-clinical, medical affairs and New Product Planning to deliver against the program strategy. The successful candidate will have leadership experience across all phases of drug development in the oncology therapeutic area, grounded in a strong foundation in biology. This role will report to the SVP, Asset Strategy and Team Leadership and can be remote, hybrid, or located at our headquarters in New Haven, CT. Principal Responsibilities Key responsibilities of this role include, but are not limited to:

• Apply relevant and up-to-date knowledge of biology, biological mechanisms of disease, and drug development to lead drug development strategy creation, lead assets to achieve their development milestones and maximize the overall long-term value of the assets, which includes: o Lead the development of long-range objectives and specify the strategies and actions to achieve them as part of the Integrated Development Plan with a multidisciplinary matrixed team.

Lead alignment on plans with governance and executive management. o Communicate with supervisor and other senior leaders, peers, and functional representatives. Collaborate with functional leads to create and evaluate detailed scenario plans based on the external landscape and business needs; Negotiate with and influence key internal and external stakeholders o Process and interpret biological and scientific information and data to continually reassess the drug development strategy and operational plan

• Lead the External Engagement subteam to ensure assets are represented externally in alignment with the Arvinas corporate strategy and the asset strategy. This includes publication and congress planning, KOL and advocacy engagement, and collaborations and partnerships. Represent employer in a technical capacity at conferences.
• Use scientific background and advanced understanding of biological systems to lead the team to make decisions, solve development strategic and operational problems, which includes: o Lead the team to coordinate strategic and operational activities of others, including Clinical Research, Clinical Operations, Regulatory, CMC, New Product Planning and Project Management to ensure strategic alignment and seamless execution to deliver the greatest value to patients, physicians, payors, and Arvinas o Lead the team to analyze biological, preclinical, and clinical information and data to identify trends or relationships among variables to choose the best solution and solve problems.

Detect changes in circumstances or events that impact plans. o Collaborate with the Project Manager on program progress, cost, resource allocation, timelines, etc. and functional team leads to proactively identify risks, resolve issues and optimize performance; Estimate and determine the time, costs, and resources needed to perform a work activity. Monitor and controlling resources. o Evaluate scientific and biological information to determine compliance with standards. Review reports and proposals, such as those relating to preclinical and clinical study results, biological data analyses, and regulatory submissions, for accuracy, adequacy, or adherence to policies, regulations, or scientific standards

• Lead cross-functional oncology asset teams and act as main point of contact and program representative to executive management.

Interpret the meaning of biological and scientific information and data for senior leaders and others in the organization to explain what information/data means and how it can be used, which includes: o Work closely with Business Development and Alliance Management on partnership opportunities and partnered programs. Communicating with people outside the organization as needed, representing the organization to customers, the public, government, and other external sources. o Represent the programs at governance and decision-making meetings o Lead and/or support other corporate objectives involving the assets including Board meeting preparation, earnings preparations and corporate presentations o Drive team objective setting, prioritization and performance to ensure adherence to plan and strategy o As a senior leader in the organization, coach and develop others. Use knowledge of drug development and scientific experience to provide consultation and advice to others. o Create a positive team environment to achieve the highest level of performance by instilling trust and ensuring clear, transparent communications, and building consensus behind the overall goal/vision for the programs. Organize, plan, and prioritizing work of the team to align with specific goals and endorsed plans.

• Partner with Research to provide scientific and drug development experience as programs advance out of exploratory research and into development Qualifications Applicants for this role are required to have both a an advanced education in biology or a closely related scientific field of study, combined with significant oncology drug development and scientific leadership experience in the biotechnology/pharmaceutical industry to be qualified for this role.

• Significant drug development leadership experience, with history of effective management of cross functional teams, key external stakeholders and partners, specifically including leadership of oncology asset teams across phases of development
• Held senior level roles in the pharmaceutical industry in which engagement with executive leaders and possibly the board of directors was required.
• Minimum of 15 years of relevant experience in the biotechnology/pharmaceutical industry with a minimum of 5 years in a scientific leadership role leading cross-functional drug development asset teams. The leadership experience needs to be specific to asset development teams and cannot be limited to functional team or subteam leadership.
• Experience in more than one drug development discipline
• Experience in hematology oncology preferred
• Based on a strong educational background in biology, health sciences, or a closely related scientific field and extensive industry experience, proven ability to apply biological expertise and scientific rigor to lead and influence data interpretation, data-driven strategy planning and implementation
• A proactive and strategic thinker, with strong decision-making skills
• Proven ability to function effectively across a matrix organization with multiple stakeholders and constituents, with the ability and strength to focus a team to work towards its goals
• Demonstrated experience in successfully leading teams: running them effectively, efficiently and on target
• Ability to work cooperatively within a cross-functional, partially virtual team setting is critical, as are strong interpersonal communication skills
• Strong leadership and communication skills (including presentation skills) with success in influencing all levels cross-functionally
• Excellent business acumen and judgment with demonstrated ability to align teams to corporate strategy to achieve business and project objectives
• Highly collaborative with outstanding relationship building skills
• The duties of this role are generally conducted in combination of company office and home office environments.

Employees must be able, with or without accommodation, to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Education

• Bachelor's degree in biology or a closely related life science field required (including but not limited to Microbiology, Chemistry, Clinical Research, or Health Science), with a minimum of 15 years of relevant experience in the biotechnology/pharmaceutical industry, including at least 5 years in a scientific leadership role; or the equivalent combination of education and experience.
• Specific training in an area of drug development, such as Clinical Research, required Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families.

Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.