Research Associate III / Associate Scientist - Chemistry Position We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape the company DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation.
Responsibilities:
Design and validate novel DEL library builds. Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space. Construct DEL libraries to support the in-house library production efforts. Work with external partners to support our DEL synthesis and hit follow up strategies. Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization. Contribute to platform automation and technology development efforts. Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.
Requirements:
B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry. 2-5 years of industrial experience (title determined by experience). Strong background in synthetic organic chemistry. Hands-on laboratory experience synthesizing DNA encoded libraries. Familiar with the overall DNA-Encoded Library Technology workflow operations. Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).