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Jobs Scientist Emp Type:

Contract South San Francisco, CA, US Wednesday, Sep 30, 2026

Salary :

47.59 - 59.49

Hourly Job Summary:

Seeking a Scientist to scale-up protein purification processes, including Affinity/IEX/HIC/MM chromatography, nanofiltration, depth filtration and ultrafiltration/diafiltration This Scientist I role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs. This position is an onsite role in a lab-based function. To be successful candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists. Scale-up protein purification processes, including Affinity/IEX/HIC/MM chromatography, nanofiltration, depth filtration and ultrafiltration/diafiltration Large scale buffer preparation to support scale-up processes Operate, troubleshoot, and maintain pilot-scale bioprocess equipment such as depth filtration systems, chromatography skids, virus filtration systems, TFF skids, mixers, tanks, pumps, and single-use assemblies Perform pre-run readiness activities, including equipment setup, column packing/qualification, buffer/media verification, and raw material staging Support incoming transfer processes to scale-up lab to support GLP toxicology study material production and outgoing transfer processes to GMP manufacturing site for clinical material production Work efficiently, collaboratively, and cross-functionally toward project timelines and goals Author standard operating procedures (SOPs), technical reports and maintain well-documented records in an electronic lab notebook (ELN) Author and deliver technical presentations Qualifications BS with 5-7 years, or MS with 2-5 years; degree in Chemical Engineering, Chemistry, Biochemistry or related discipline Hands on experience with mAb purification unit operations, including Affinity/IEX/HIC chromatography, nanofiltration, ultrafiltration/diafiltration, preferably with scale-up or GMP manufacturing; experience with scale-up equipment such as AKTA Ready/Process, single use mixers, TFF skids Experience authoring standard operating procedures (SOPs) and reports, and maintaining well-documented records in an Electronic Lab Notebook Must have CMC protein purification development experience with standard bioprocess unit operations such as chromatography separations (resin/membrane: affinity, CEX, AEX, HIC, MM) and filtration operations (depth filtration, virus filtration, sterile filtration, TFF) Must have excellent attention to detail and ability to keep detailed written records Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions Demonstrated ability to learn, understand and master new experimental techniques Able to work collaboratively within and outside of the group Able to author technical reports and presentations Has understanding of biochemistry and bioprocess engineering concepts Has strong planning and analytical skills Experience with AKTA chromatographic instruments (such as AKTA Ready, AKTA process, AKTA Avant, AKTA Purifier, AKTA Pure or similar), TFF skids (such as Sartoflow 1000 or similar) Demonstrated scientific writing skills and strong verbal communication skills including scientific data presentations Has proficiency with Microsoft Office software, ability to learn new software applications

Preferred Qualifications:

Has hands on experience with executing antibody or antibody-like molecule purification techniques including resin chromatography (affinity, CEX, AEX, MMC), depth filtration, virus filtration, membrane chromatography, and TFF operations, preferably at pilot or GMP scale Has hands on experience with unit operation development including cell culture harvest, affinity chromatography, polishing chromatography, virus filtration and ultrafiltration/diafiltration. Understanding of analytical techniques, such as HPLC, LAL, and ELISA Has hands on experience with high-throughput technologies and automation

Benefits:

Healthcare Insurance:

Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance:

Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance:

Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. 401(k)

Plan:

The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins. Synectics is an equal opportunity employer.