Key Responsibilities

• Develop, optimize, characterize, and validate fit-for-purpose analytical methods supporting lentiviral vector and CAR-T cell characterization, with emphasis on multicolor flow cytometry, cell-based assays, and molecular methods.
• Design and execute experiments to establish assay conditions and evaluate performance characteristics, including accuracy, precision, specificity, sensitivity, linearity, range, and robustness, as applicable to the method and its intended use.
• Review scientific literature and emerging technologies to inform assay development, improve existing methods, and identify new analytical capabilities relevant to cell and gene therapy.
• Perform established analytical assays supporting internal programs and external client projects, including CAR-T phenotypic and functional characterization and lentiviral vector functional titer assays.
• Perform supporting cell and molecular biology techniques, including mammalian cell culture, cloning, DNA/RNA purification, in vitro transcription, qPCR, and dPCR.
• Critically analyze and interpret experimental data, assess assay performance and data quality, identify sources of biological or technical variability, troubleshoot unexpected results, and define scientifically justified next steps.
• Maintain accurate and complete experimental records and prepare analytical methods, protocols, qualification or validation documentation, technical reports, and data summaries.
• Communicate scientific results, conclusions, technical challenges, and recommendations to internal project teams and external clients, as appropriate.
• Collaborate across multidisciplinary project teams and manage multiple analytical activities and changing priorities while maintaining scientific rigor, data integrity, and project timelines. Essential Qualifications
• PhD or MSc in Immunology, Virology, Molecular Biology, or a related field, with relevant experience in viral vectors and CAR-T cell therapy.
• Extensive hands-on experience with cell-based and multiparameter flow cytometry assays, including assay optimization, panel design, gating strategies, and data analysis.
• Experience with qPCR and/or dPCR; experience with lentiviral vector or CAR-T characterization is preferred.
• Demonstrated experience in analytical method development and characterization, including experimental design, assay performance assessment, and troubleshooting.
• Strong scientific judgment and analytical skills, with the ability to critically interpret data, investigate variability, and define appropriate next steps.
• Ability to independently review scientific literature and apply relevant findings or emerging technologies to assay development.
• Strong scientific writing, documentation, and communication skills.
• Self-motivated, detail-oriented, collaborative, and adaptable to changing project priorities and workloads.

Preferred :

Experience with assay qualification/validation in a biotechnology, pharmaceutical, or CRO environment and/or NGS and associated bioinformatic analysis. Type Full time Compensation and benefits Salary is commensurate with experience and qualifications. A comprehensive benefits package including but not limited to: Paid Holidays PTO Health insurance Employer paid Short- and Long-Term Disability Life Insurance AD&D Dental Insurance Simple IRA with an employer match

Pay:

$80,000.00 - $100,000.00 per year

Benefits:

401(k) Dental insurance Health insurance Relocation assistance Vision insurance Application Question(s): Do you have hands-on experience with cell-based and multiparameter flow cytometry assays, including assay optimization, panel design, gating strategies, and data analysis? Do you have Experience with qPCR and/or dPCR? Do you have experience with lentiviral vector or CAR-T characterization? Do you have experience with assay qualification/validation in a biotechnology, pharmaceutical, or CRO environment and/or NGS and associated bioinformatic analysis?

Education:

Master's (Preferred)

Work Location:

In person