At AstraZeneca, we're building a different kind of biopharmaceutical company—one that redefines how transformational oncology medicines are conceived, developed, and delivered. Oncology Targeted Discovery accelerates impact by attacking cancer from multiple angles through innovative modalities, combinations, and precision regimens. The Director, Theranostics and Radiation Science will play a key role in supporting the management, mentorship, and development of the Radiation Sciences team. You will help guide and support team members, fostering collaboration and professional growth within the team. In addition to leadership, you will oversee key processes and work cross-functionally with divisions across Imaging and Radioconjugate development , including but not limited to Clinical Operations, Preclinical Teams, Pharmacometrics, DMPK, and Regulatory Affairs. The role will also involve working with and helping manage external vendors and contractors to ensure the successful execution of ongoing and upcoming clinical trials. This position requires a scientific and strategic mindset, stron g technical background , and the ability to navigate complex projects while collaborating effectively across internal and external stakeholders. Responsibilities Optimize and review nuclear medicine imaging protocols, including quality control parameters, image acquisition and reconstruction, radiation dose determination, and protocol dose management. Define requirements and technical support for imaging execution at clinical sites, ensuring proper implementation and adherence to study protocols. Design and oversee quality control protocols, working with both internal teams and external partners for imaging review and processing. Provide training, mentorship, and problem-solving support to internal and external clinical study teams to ensure study objectives are met. Perform image-based, patient-specific dosimetry calculations (internal dosimetry, not external beam radiation therapy [EBRT]). Collaborate with the Radiation Sciences team on imaging protocol optimization, ensuring alignment with best practices in QC, image acquisition, radiation dose management, and compliance with regulatory standards. Support regulatory compliance efforts related to radioactive materials, staying current with guidelines from regulatory and professional organizations (e.g., SNMMI, NRC, and international regulatory bodies). Contribute to research and discovery projects as needed, providing scientific and technical expertise to advance innovation in radiation sciences and molecular imaging. Basic Qualifications BS degree in physical sciences , mathematics or other physical sciences followed by a graduate degree (M.S. or PhD) in medical physics, physics or related scientific disciplines. Medical physics residency or Post Doctoral training with 5 + years of Industry and/or clinical experience (post residency) . Knowledge and Experience with personalized dosimetry for radiopharmaceuticals, experience with programs such as Olinda, MIM and other imaging and dosimetry packages is required . Preferred Qualifications Board certification is preferred but not required . Prior industry experience is preferred but not required . Experience with radiopharmaceuticals, Nuclear Medicine, SPECT and PET imaging techniques, reconstruction, and camera quality control procedures are preferred. Strong concepts in radiation biology and radiation physics are preferred. Advanced technical computer skills and thorough understanding of modern electronic infrastructures relevant to radiological imaging such as

DICOM, PACS

is required and , client/server architectures and image processing is preferred. Understanding of imaging-related project needs as expressed in a clinical study protocol. Experience with radioactive materials regulations or guidelines from regulatory organizations and professional organizations, (e.g. AAPM , SNMMI, NRC, and other country regulatory bodies) The annual base salary for this position ranges from $203,709-.305,564 However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Date Posted 01-Sept-2026 Closing Date 27-Dec-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.