Lead Antibody Engineer

Lead Antibody Engineer

• Rockville, MDOur client in the biotechnology industry is looking to expand their Antibody Engineering team in Rockville, MD and is in search of a Lead Antibody Engineer who specializes in guided phage display and the development of antibody discovery technologies.

Key Responsibilities:

• Lead the advancement of innovative phage display techniques — including guided selection methods, structure-informed panning, and epitope-focused approaches — to enhance platform capabilities beyond traditional execution methods.
• Utilize deep mutational scanning and NGS-based repertoire analysis to gain mechanistic insights, inform library designs, and create predictive models of antibody fitness landscapes.
• Pioneer new phage display selection strategies for complex targets like membrane proteins and conformational epitopes.
• Contribute to intellectual property and drive industry advancements through inventorship and impactful publications.
• Collaborate with structural biologists to utilize cryo-EM, crystallography, and molecular dynamics data for informed engineering decisions.
• Incorporate AI/ML and computational tools into phage display workflows, utilizing generative protein design, protein language models, and in silico affinity predictions to expedite lead discovery and optimization.

Qualifications:

• PhD in Molecular Biology or related discipline.
• Proven experience in advanced phage display techniques with a focus on method and technology development.
• Strong track record of high-impact publications is desirable.
• Passion for bridging experimental and computational antibody engineering realms.