Competitive salary based on experience, plus performance incentives as the operation scales About the role We are building a high-performance peptide analytical testing operation and are seeking a highly hands-on Founding General Manager / LC-MS Peptide Testing Operations Manager to lead it from the ground up. This is not a corporate management-only position. Initially, you will personally run the lab, operate and maintain analytical equipment, develop and improve methods, organize sample flow, establish documentation systems, and build the SOPs required to scale into a disciplined, reliable testing operation. The ideal candidate has deep practical experience analyzing peptides using
UPLC/HPLC
coupled to high-resolution mass spectrometry, especially Waters platforms such as an ACQUITY UPLC and Xevo QTof system. You will help turn a capable instrument platform into a repeatable, well-documented analytical operation. What you'll do Operate, troubleshoot, maintain, and optimize peptide analytical workflows using UPLC/HPLC and high-resolution LC-MS, including QTof systems. Develop and refine LC-MS methods for peptide identity confirmation, purity assessment, impurity profiling, degradation studies, and stability testing. Build laboratory SOPs for sample receipt, chain of custody, preparation, dilution, injection, sequence setup, system suitability, data processing, review, reporting, cleaning, maintenance, and deviations. Establish practical quality systems, including logbooks, instrument maintenance records, reagent and standard tracking, data review workflows, and controlled documentation. Create reliable workflows for analytical method transfer, method qualification/validation planning, and batch-to-batch comparability. Interpret LC-MS data, including accurate mass, charge-state envelopes, deconvolution, adducts, retention behavior, impurity patterns, and peptide degradation products.
