Medical Director - Hematology Position Summary The Medical Director provides medical oversight for assigned clinical trials and serves as the primary medical resource for investigators and study teams. This individual is responsible for ensuring participant safety, supporting protocol execution, reviewing clinical data, and contributing to high-quality study conduct in accordance with GCP, regulatory requirements, and company objectives. Working collaboratively across Clinical Development, Clinical Operations, Safety, Biometrics, Regulatory Affairs, and external partners, the Medical Director helps ensure studies are conducted efficiently while maintaining scientific integrity and patient safety. Key Responsibilities Medical Oversight Serve as the medical monitor for one or more clinical studies. Review safety data and emerging clinical information throughout study conduct. Provide timely medical guidance to investigative sites and CRO partners. Participate in eligibility reviews, protocol deviation assessments, and subject management discussions. Review serious adverse events (SAEs), adverse events of special interest (AESIs), and other safety information in collaboration with Pharmacovigilance. Support medical decision-making regarding dose modifications, discontinuations, and subject management. Study Conduct Partner with Clinical Operations to support successful study execution. Participate in investigator meetings, site training, and study initiation activities. Contribute to protocol development, informed consent documents, and study-related medical materials. Review clinical data for consistency, trends, and subject safety. Participate in data review meetings and support database lock activities. Cross-functional Collaboration Work closely with Clinical Operations, Biometrics, Medical Writing, Regulatory Affairs, and Pharmacovigilance. Provide medical input for regulatory submissions and responses to health authorities. Support, safety review meetings as needed. Contribute to preparation of clinical study reports and publications. External Relationships Develop productive relationships with investigators andkey opinion leaders Serve as a medical representative for assigned studies during internal and external meetings. Qualifications Education MD required. Board certification or board eligibility in hematology / oncology. Experience 5+ years of clinical experience and/or pharmaceutical or biotechnology industry experience. Experience serving as a Medical Monitor or Medical Director for interventional clinical trials. Experience supporting Phase 1 clinical studies in hematology / oncology preferred.. Knowledge & Skills Strong understanding of

ICH-GCP, FDA

regulations, and clinical trial conduct. Experience reviewing safety data and making medical decisions during clinical trials. Ability to interpret clinical data and identify emerging safety signals. Excellent communication and interpersonal skills. Comfortable working in a fast-paced biotech environment with significant cross-functional collaboration. Strong organizational skills and attention to detail. Preferred Attributes Collaborative team player who enjoys working across functions. Able to balance strategic thinking with hands-on execution. Comfortable working with external CROs and investigators. Demonstrates sound medical judgment and a patient-focused mindset. Thrives in a dynamic, evolving biotech environment. Operate with a high degree of independence while partnering closely with cross-functional teams. Contribute to clinical development strategy beyond day-to-day study oversight. Support due diligence, investigator engagement, and program planning as needed. Willingness to take on responsibilities that evolve with the company's pipeline and stage of development. This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $302,276 - $370,530. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states. Recruitment fraud statement Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself: Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline. We do not conduct interviews through RingCentral, Skype or Telegram. Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website. You can find more information about job scams at consumer.ftc.gov/articles/job-scams. To report job scams, head to ReportFraud.ftc.gov. Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters) The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.