6-Month Initial Contract We are seeking a highly motivated and creative scientist or engineer with process development experience to join an Oligonucleotide / Peptide Purification Development team . This position offers the opportunity to develop robust, high-purity purification processes for oligonucleotide and peptide therapeutics and gain hands-on exposure to the design, development, scale-up, and transfer of manufacturing processes supporting clinical and commercial programs. The successful candidate will contribute to the development of novel purification technologies and processes, working across laboratory, pilot-scale, and manufacturing environments. Key Responsibilities Develop and characterize purification processes for oligonucleotide and peptide therapeutics , including process development, process characterization, robustness studies, and scale-up. Support purification unit operations including chromatography, detritylation, and ultrafiltration/diafiltration (UF/DF) . Utilize multiple chromatography modes and support or learn additional processing steps including chemical cleavage, conjugation, and hybridization . Investigate novel purification technologies and approaches designed to improve purity, process robustness, and productivity . Support early- and late-stage process characterization and robustness studies. Scale up and transfer oligonucleotide purification processes into pilot-scale and GMP manufacturing facilities . Contribute to technology transfer activities , manufacturing documentation review, troubleshooting, and on-the-manufacturing-floor support. Support root cause investigations and process evaluations , working independently where appropriate with guidance from the supervisor. Collaborate cross-functionally with teams supporting synthesis, drug product, analytical development, research, manufacturing, project management, and technology transfer . Document laboratory and development activities through development reports and other technical documentation . Lead or support pilot-scale activities and small, focused technical initiatives. Provide training and mentoring to new employees as appropriate. Participate in the preparation and authoring of CMC/regulatory sections for IND submissions . Qualifications Demonstrated experience successfully planning and executing scientific projects and experiments . Hands-on laboratory experience with the purification of proteins, peptides, and/or DNA/RNA . Experience using column chromatography , such as: Ion exchange chromatography Hydrophobic interaction chromatography Reversed-phase chromatography Experience with ultrafiltration/diafiltration (UF/DF) . Hands-on experience analyzing proteins, peptides, and/or DNA/RNA, preferably using HPLC and UV/Vis spectroscopy . Demonstrated technical proficiency and creativity in developing or evaluating purification technologies and approaches . Strong organizational, written, and verbal communication skills. Ability to work effectively both independently and within cross-functional teams . Preferred Qualifications Experience with ÄKTA purification systems and UNICORN software . Experience with Design of Experiments (DoE) . Experience with statistical analysis . Experience with process scale-up, technology transfer, or GMP manufacturing environments is beneficial. Education & Experience Associate Scientist 3 / Engineer 2 Bachelor's degree in Biochemistry, Chemical Engineering, Chemistry, or a related life science field with 2-4 years of industry experience ; or Master's degree in a related field with 0-2 years of industry experience . Senior Associate Scientist Bachelor's degree in Biochemistry, Chemical Engineering, Chemistry, or a related life science field with 4+ years of industry experience ; or Master's degree in a related field with 2+ years of industry experience . ...
