Top 10 Data Analysis & Mathematics Jobs in South Carolina (+ Salaries)

Unless otherwise noted, all labor market data in this article is sourced from Lightcast/U.S. Bureau of Labor Statistics, current as of April 2026.

South Carolina’s growing tech and healthcare sectors are creating significant opportunities for professionals skilled in data analysis and mathematics. With roles offering median salaries up to $191,585 and many positions experiencing steady growth, now is an excellent time to explore these in-demand careers across the Palmetto State.

Explore High-Paying Data Analysis & Mathematics Careers in South Carolina

1. Biostatistics Manager / Director

A Biostatistics Manager or Director leads a team of statisticians, overseeing the statistical analysis and reporting of health and biology-related data. This work is crucial for product development in pharmaceutical companies, disease research in hospitals, or health policy research in public health organizations. You would direct the design of statistical analysis, review findings, and may manage regulatory reporting for projects like clinical trials.

Salary Range: Entry-level positions start around $139,073, with a median salary of $191,585 and top earners reaching $255,701.
Demand & Growth: This role has low demand with 11 active postings in South Carolina, but is projected to grow by 4.7%.
Top Skills: Leadership, Innovation, Research, Communication, and Writing.
Salary-Boosting Skills: Statistical Programming, Pre-Clinical Development, and Clinical Study Design.
Top Employers in South Carolina: Sumitomo Pharma, Cytel, Travere Therapeutics, Padagis Us, and United Therapeutics Corporation.
Career Advancement: You could advance to a Director of Clinical Research, potentially increasing your earnings by an average of $22,826.

2. Data Science Manager

As a Data Science Manager, you would lead a team of data scientists, machine learning engineers, and big data specialists. Your responsibilities include overseeing data mining and collection, ensuring data quality and integrity, building analytic systems and predictive models, and testing the performance of data science products.

Salary Range: Entry-level salaries are around $111,877, with a median of $184,866 and top salaries reaching $215,378.
Demand & Growth: This role has low demand with 55 active postings in South Carolina, with a projected growth of 5.8%.
Top Skills: Leadership, Communication, Innovation, Research, and Mathematics.
Salary-Boosting Skills: Artificial Intelligence, Algorithms, and Machine Learning.
Certifications that Boost Pay: Functional Skills Qualification (5%) and Master Of Business Administration (MBA) (5%).
Top Employers in South Carolina: TD Bank, S&P Global, General Motors, Confluent, and Merck & Co.

3. Deep Learning Engineer

A Deep Learning Engineer designs, deploys, and optimizes deep learning models and algorithms. You would train models using frameworks like TensorFlow, PyTorch, and Keras, and evaluate their accuracy. This role often involves close collaboration with data scientists, software engineers, and other stakeholders to develop solutions that meet business needs.

Salary Range: Entry-level positions typically earn around $78,151, with a median salary of $148,278 and top earners making $206,600.
Demand & Growth: This role has low demand with 6 active postings in South Carolina, and is projected to grow by 4.1%.
Top Skills: Teaching, Communication, Curiosity, Self-Motivation, and Problem Solving.
Salary-Boosting Skills: Optimizing Compilers, TensorFlow, and Deep Learning.
Top Employers in South Carolina: Teradata Operations, Irmo High School – School District Five Of Lexington & Richland Counties, South Carolina, Clemson University, and Omnisight.

4. Artificial Intelligence Engineer (General)

An Artificial Intelligence Engineer develops, tests, and deploys artificial intelligence models. You would collaborate closely with data software engineers and other data professionals to train and implement AI models into existing systems or develop entirely new applications.

Salary Range: Entry-level salaries start at $91,416, with a median of $140,659 and top salaries reaching $189,813.
Demand & Growth: This role has low demand with 93 active postings in South Carolina, and is projected to grow by 3.6%.
Top Skills: Communication, Innovation, Problem Solving, Leadership, and Research.
Salary-Boosting Skills: Ethical AI, Edge Intelligence, and Computer Science.
Certifications that Boost Pay: Microsoft Certified Professional (3%), Top Secret-Sensitive Compartmented Information (TS/SCI Clearance) (3%), and Certified Application Developer (2%).
Top Employers in South Carolina: General Motors, PricewaterhouseCoopers, Teradata Operations, Nelnet, and Lenovo.
Career Advancement: Potential paths include Data Science Manager (+$18,142) or Software Development / Engineering Manager (+$17,949).

5. Machine Learning Engineer

A Machine Learning Engineer specializes in designing, building, and deploying machine learning models. You would utilize statistical and mathematical techniques, parallelizing processing, hyperparameter tuning, and other optimization methodologies to improve model performance. Responsibilities also include collecting and preprocessing large datasets, conducting exploratory data analysis, and working closely with data engineers to understand data requirements and engineer input variables for machine learning models.

Salary Range: Entry-level positions typically earn around $93,779, with a median salary of $121,424 and top earners making $146,742.
Demand & Growth: This role has medium demand with 122 active postings in South Carolina, and is projected to grow by 4.1%.
Top Skills: Communication, Research, Forecasting, Innovation, and Problem Solving.
Salary-Boosting Skills: Artificial Intelligence, Computer Vision, and Computer Science.
Certifications that Boost Pay: Certified Information Systems Security Professional (3%), Certified Cloud Security Professional (CCSP) (2%), and Secret Clearance (2%).
Top Employers in South Carolina: Launch Potato, S&P Global, General Motors, Ford, and Booz Allen Hamilton.

6. Actuary

An Actuary calculates the financial costs of risk and uncertainty. You would use findings from statistical analysis and mathematical modeling to help businesses and clients minimize the cost of risk and develop business and investment strategies. This often involves using actuarial analysis of the probability and cost of natural disasters or accidents to develop insurance policies.

Salary Range: Entry-level salaries are around $78,804, with a median of $118,143 and top salaries reaching $165,878.
Demand & Growth: This role has medium demand with 127 active postings in South Carolina, with a strong projected growth of 6.2%.
Top Skills: Management, Communication, Leadership, Problem Solving, and Research.
Salary-Boosting Skills: Economic Capital.
Certifications that Boost Pay: Actuarial Exams (75%), Associate Of The Society Of Actuaries (53%), and Fellow Of The Society of Actuaries (43%).
Top Employers in South Carolina: Lincoln Financial Group, Humana, Unum, Prime Therapeutics, and Blue Cross Blue Shield.
Career Advancement: You could advance to a Financial Quantitative Analyst (+$25,658), Analytics Product Manager (+$17,621), or Data Analytics Manager (+$16,532).

7. Data Analytics Manager

A Data Analytics Manager leads and develops a team of data analysts. You would be responsible for selecting, configuring, and implementing analytic solutions; creating strategies for effective data analysis and reporting; and building systems to transform raw data into actionable business insights.

Salary Range: Entry-level positions start around $92,165, with a median salary of $118,550 and top earners reaching $157,558.
Demand & Growth: This role has low demand with 91 active postings in South Carolina, and is projected to grow by 5.8%.
Top Skills: Leadership, Communication, Management, Problem Solving, and Operations.
Salary-Boosting Skills: Data Science.
Certifications that Boost Pay: Master Of Business Administration (MBA) (12%), Project Management Professional Certification (4%), and Valid Driver’s License (2%).
Top Employers in South Carolina: Prime Therapeutics, PricewaterhouseCoopers, Merkle, LPL Financial, and Lumen Technologies.
Career Advancement: Potential paths include Data Science Manager (+$43,492) or Director of Communications (+$24,489).

8. Natural Language Processing Engineer

A Natural Language Processing Engineer specializes in developing and implementing algorithms and models tailored for understanding, processing, and generating natural language text. You would utilize methodologies such as tokenization, parsing, named entity recognition, part-of-speech tagging, and other NLP techniques to perform tasks including text classification, chatbot development, and other applications where the primary input or output is natural language text.

Salary Range: Entry-level salaries are around $84,829, with a median of $118,958 and top salaries reaching $179,295.
Demand & Growth: This role has low demand with 60 active postings in South Carolina, and is projected to grow by 4.1%.
Top Skills: Mathematics, Innovation, Communication, Decision Making, and Research.
Salary-Boosting Skills: Deep Learning Methods, Language Models, and Generative Adversarial Networks.
Certifications that Boost Pay: Secret Clearance (5%), Microsoft Azure Certification (3%), and Security Clearance (3%).
Top Employers in South Carolina: Cardinal Health, CVS Health, United States Department of Energy, Stiftelsen Norstella, and Stride K12.
Career Advancement: You could advance to a Data Science Manager (+$25,849) or Software Development / Engineering Manager (+$25,656).

9. Biostatistician

A Biostatistician conducts statistical analysis of health and biology-related data. This analysis may be used for product development at a pharmaceutical company, disease research at a hospital, or health policy research at a public health organization.

Salary Range: Entry-level positions typically earn around $81,412, with a median salary of $109,249 and top earners making $162,365.
Demand & Growth: This role has low demand with 32 active postings in South Carolina, and is projected to grow by 4.7%.
Top Skills: Communication, Research, Management, Presentations, and Writing.
Salary-Boosting Skills: Pharmacoepidemiology, Statistical Programming, and Data Analysis.
Certifications that Boost Pay: Valid Driver’s License (3%).
Top Employers in South Carolina: Cytel, University of South Carolina, Bluecross Blueshield of South Carolina, Novotech International, and Humana.
Career Advancement: Potential paths include Biostatistics Manager / Director (+$76,598), Research Scientist (+$13,849), or Director of Clinical Research (+$99,424).

10. Generative Artificial Intelligence Engineer

A Generative Artificial Intelligence Engineer develops, designs, and manages generative models and algorithms that support the creation of new content in the form of images, text, audio, and other multimedia. You would utilize GPTs, GANs, VAEs, and other deep learning architectures to craft systems capable of generating data, often working with data scientists, machine learning engineers, and software developers.

Salary Range: Entry-level salaries start at $67,514, with a median of $109,866 and top salaries reaching $154,455.
Demand & Growth: This role has low demand with 74 active postings in South Carolina, and is projected to grow by 4.1%.
Top Skills: Communication, Problem Solving, Innovation, Leadership, and Research.
Salary-Boosting Skills: AI Research and Generative Adversarial Networks.
Certifications that Boost Pay: Valid Driver’s License (3%), Certified Cloud Security Professional (CCSP) (1%), and Microsoft Certified: Azure Data Engineer Associate (1%).
Top Employers in South Carolina: PricewaterhouseCoopers, Avanade, Lumen Technologies, SitusAMC, and Cengage Learning.

Ready to dive into a career in data analysis or mathematics in South Carolina? Explore these exciting opportunities and discover how your skills can lead to a rewarding future. Create a free profile on Tallo.com to connect with colleges and companies looking for talent like yours.