Senior Director, Quantitative Pharmacology and Pharmacometrics Position Available In Richland, South Carolina

•Job Description•The Quantitative Pharmacology and Pharmacometrics (QP2) department drive model-informed drug discovery and development (MIDD) to routinely enable efficient drug discovery/development and/or regulatory decisions. The Pharmacometrics group within QP2 brings an experienced leadership team, deep modeling expertise and state-of-the-art modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through life-cycle management. The team is externally visible and continues to be at the leading edge of building innovative state of the art tools. With MIDD as an essential component of decision-making at our Company, this position offers an opportunity for the Pharmacometrics leader to drive pipeline impact and lead a talented group of pharmacometricians. This Senior Director is expected to be an experienced pharmacometrician with a strong, understanding of the integrated strategic elements of drug discovery and development and the ability to incorporate Modeling and Simulation (M&S) tools in decision making to drive pipeline impact. She/he will take on primary responsibilities for identifying emerging areas of pharmacometrics innovation and leading QP2 efforts to strengthen our pharmacometrics capabilities on a continuous basis. The Senior Director will be accountable for directing a team of pharmacometricians with diverse backgrounds and bringing subject matter expertise related to model informed drug discovery and development for programs. •The Senior Director in Pharmacometrics should provide strategic leadership for pharmacometrics through the following responsibilities:•+ Guide a team of approximately 5-10 pharmacometricians to achieve results on major program drivers by identifying and implementing quantitative approaches (for e.g., translational PK/PD models, population pharmacokinetic models, exposure-response models, quantitative system pharmacology (QSP) and disease progression models, clinical trial simulations, comparator modeling) that seek to improve cycle time, cost/size and number of trials, implementation of tools and framework for driving Go/No Go decisions on programs and rapid regulatory approvals + Foster collaboration within QP2 to achieve results, remove barriers on portfolio or scientific priorities + Evaluate and maintain appropriate quality systems and IT infrastructure for QP2 to support emerging capabilities + Responsible for priority-setting, performance management, hiring and retention, talent development/management for direct reports + Identify resource needs and contribute to resource allocation internally and through management of business operations and outsourcing budgets + Provide functional representation on committees, task forces or initiatives spanning beyond QP2 + Initiate and manage external collaborations to develop new methodologies and lead our external outreach to the scientific pharmacometrics community •

Required Experience:

•+ (a Ph.D. or equivalent degree with ≥ 12 years of experience where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia + Educational background in pharmacometrics, pharmaceutical sciences, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field + At least 10 years of discovery/drug development/regulatory experience + Deep expertise in pharmacometrics (e.g., population PK and PK/PD analyses, model-based meta-analysis, dose-response and exposure-response analyses, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modeling) with ability to understand how MIDD can drive portfolio and regulatory decisions + Extensive experience in developing quantitative strategies for impacting pipeline decisions + Good interpersonal and communication skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise _This (remote) position is only applicable for those that are not within commutable distance to primary sites noted in posting. If commutable, the position will be hybrid_ _._ _Please note that standard commute is (less than)