Associate Director Crystallization (Apply in 3 Minutes) Position Available In Middlesex, Massachusetts

Job Description:

About the Job We are an innovative global healthcare companywith one purpose: to chase the miracles of science to improvepeople’s lives. We’re also a company where you can flourish andgrow your career, with countless opportunities to explore, makeconnections with people, and stretch the limits of what you thoughtwas possible. Ready to get started?

Position Overview/DepartmentDescription:

We are looking for a highly motivated individual witha mindset to lead the implementation of changes. She/He will berecognized as technical expert in the field of crystallization andsolid-state chemistry and will have leadership experience. Thesuccessful candidate will work in a cutting-edge scientific globalcrystallization department in Sanofi’s R D CMC Syntheticorganization. The job is in Cambridge MA, but close collaborationwith colleagues in France is required. Crystallization Scientistswork cross functionally to select active pharmaceutical ingredients(API) solid forms for development and deliver robust commercial APIcrystallization processes. Process development may be directed toeither batch or continuous processes. Collaborative work withChemists and Engineers on complex drug substance intermediatecrystallizations will also be required. Work starts at candidateselection and continues to commercial launch. We strongly believethat innovation in process development, data science and modellingwill be key drivers to transform Pharma process development.

KeyResponsibilities:

• Lead a team that works with internal partnersin Drug Product development, Biopharmaceutics and Analytical toselect the API physical form for new NCEs. This includes assessmentof the manufacturability (API solid form space complexity, physicalproperties, scalability, stability)
• Develop and mentor others todevelop processes to consistently produce API with the requiredquality attributes using both batch and continuous platforms.

Expectations include;

• Team Interactions
• Facilitate closeinteractions with project team members such as Chemists, Analysts,Formulators and Engineers/Modelers to develop API processes thatare closely coordinated with API route selection and Drug Productdevelopment.
• Digital Development
• Lead the transformation ofdevelopment from traditional data driven statistical approaches tomore efficient and effective Digital Development.
• Domainknowledge
• Use a strong background in Crystallization Engineeringand/or Solid-State Chemistry to understand and apply strategies tocontrol API physiochemical properties such as particle sizedistribution, impurities concentration and crystal form.
• Experimentation
• Apply strong lab skills to deliver well designedefficient experimental plans required for process developmentacross a wide range of crystallization, isolation and sizereduction process equipment.
• Analytical
• Perform physiochemicalanalysis to understand process and characterize products thisincludes but is not limited to XRD, DSC, PSD, SEM, opticalmicroscopy, LC, GC, KF.
• The candidate will be expected todedicate part of their time to work on continuous improvement withinternal resource or through academic collaboration. Some potentialareas for improvement include;
• Development of models tounderstand and describe the rejection of impurities in intermediateand API crystallizations.
• Develop crystallization models (DigitalTwins) for batch and continuous process and use Global SystemAnalysis tools (e.g. gPROMS) to identify CPPs, Design Space andControl Strategies.
• Identify and test Particle Engineeringapproaches to improve API physical properties such assupersaturation control, seed conditioning and agglomeration.
• Author publications, patents and present in technical conferences
• Lead Tech Transfer of crystallization to the Pilot Plant andManufacturing. This includes support for technical and HSE riskassessments, review of Master Batch Records and campaign coveragefor key batches.
• Provide concise technical presentations tocommunicate work to project teams, cross functional teams andmanagement. Document all work on projects and continuousimprovements in eLNB experiments and summarize in TechnicalReports.
• Establish/extend external network by providingleadership on academic, industrial, or government sponsoredcollaborations.

Steer collaboration projects to address gaps inscientific knowledge. About you

Basic Qualifications:

• PhD inChemical engineering or Solid State Chemistry or any related fieldwith a minimum of 6 years of experience or Masters’ degree with aminimum of 10 years of experience in academia or industry.
• Proventrack record developing and leading other to developcrystallization processes.
• An ability to work as part of a team,engaging other scientists with complementary skill sets in thefield of pharmaceutical development.
• A change agent mentality,proposing novel approach to challenging scientific questions andexploring new modeling approaches.
• Ability to design and deliverlab experimental plans for crystallization process developmentincluding use of typical process and analytical experiment.
• Familiar with PAT and common off-line analytical technics such as

HPLC, GC and NMR Preferred Qualifications:

• Modeling experienceusing gPROMS, DynoChem, Matlab, Python or similar programminglanguages.
• Some knowledge in Multivariate Analysis, chemometricsand statistics
• Experience in the development and scale-up ofcontinuous processes Why Choose Us?
• Bring the miracles of scienceto life alongside a supportive, future-focused team.
• Discoverendless opportunities to grow your talent and drive your career,whether it’s through a promotion or lateral move, at home orinternationally.
• Enjoy a thoughtful, well-crafted rewards packagethat recognizes your contribution and amplifies your impact.
• Takegood care of yourself and your family, with a wide range of healthand wellbeing benefits including high-quality healthcare,prevention and wellness programs and at least 14 weeks’gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliatesare Equal Opportunity and Affirmative Action employers committed toa culturally diverse workforce. All qualified applicants willreceive consideration for employment without regard to race; color;creed; religion; national origin; age; ancestry; nationality;marital, domestic partnership or civil union status; sex, gender,gender identity or expression; affectional or sexual orientation;disability; veteran or military status or liability for militarystatus; domestic violence victim status; atypical cellular or bloodtrait; genetic information (including the refusal to submit togenetic testing) or any other characteristic protected by law.

GD-SA LI-SA

LI-Onsite VHD All compensation will be determinedcommensurate with demonstrated experience. Employees may beeligible to participate in Company employee benefit programs, andadditional benefits information can be found here.