(Senior) Scientist, Protein Design Position Available In Suffolk, Massachusetts

(Senior) Scientist, Protein Design
Boston, MA USA About Abiologics Abiologics is a Flagship Pioneering company developing Synteins™ — a transformative class of fully synthetic proteins composed entirely of artificial building blocks such as D-amino acids and non-canonical residues. SynteinsTM are designed to transcend the limitations of traditional biologics, with improved oral stability, immune evasion, and metabolic durability — all while being fully programmable by design. Powered by a proprietary AI-enabled discovery platform, Abiologics integrates generative design, automated synthesis, and rapid experimental screening to enable iterative optimization at scale. Position Summary We are seeking a Protein Design Scientist to drive the structure-based design and optimization of synthetic proteins. This is a highly interdisciplinary role at the interface of computational design, structural biology, and protein engineering. Ideal candidates have deep experience in de novo protein design, miniproteins, and binder engineering and are eager to push the boundaries of non-natural protein design in a fast-moving, data-rich environment. Key Responsibilities Design and execute SynteinsTM engineering campaigns to generate drug candidates
Create computational design strategies to deliver drug candidates drawing from array of ML tools and Rosetta scripts
Collaborate with computation, chemistry, and experimental biology teams to optimize designs for function, solubility, and stability
Integrate structural and biophysical data (e.g., BLI binding, CD, HDX-MS, CryoEM) into iterative optimization cycles Qualifications Required PhD in structural biology, biophysics, protein design, or related field
2+ years of hands-on experience in structure-guided protein design
Demonstrated proficiency with modern structure prediction and design tools such as RFdiffusion, proteinMPNN, AF2, ESMFold, Boltz, Rosetta or equivalent SOTA tools for in-silico protein engineering
Strong understanding of the biophysics of protein folding and interface energetics
Demonstrated ability to progress designs from concept to experimental testing
Excellent communication skills Preferred Experience designing minibinders or proteins