PBPK Modeling Senior Scientist Position Available In Suffolk, Massachusetts

Job Description:

By clicking the “Apply” button, I understand that my employmentapplication process with Takeda will commence and that theinformation I provide in my application will be processed in linewith Takeda’s Privacy Notice and Terms of Use . I further attestthat all information I submit in my employment application is trueto the best of my knowledge. Job Description Objective /

Purpose:

.The Global Drug Metabolism, Pharmacokinetics and Modeling(DMPK&M) department at Takeda is seeking a strong candidate tobe a part of the Physiologically Based Pharmacokinetic (PBPK)modeling team for supporting drug-drug interaction (DDI) and PKprediction in Takeda’s global research and development pipeline forall therapeutic areas The candidate is expected to havedemonstrated experience in conducting PBPK modeling using Simcyp,Gastroplus, PKSim or other relevant software

Accountabilities:

Asuccessful candidate will be responsible for the design andimplementation of PBPK models for small molecules andbiotherapeutics supporting discovery and development programs. Theaccountabilities of this role include but are not limited to -Develop the PBPK framework for preclinical species and humans inSimcyp, Gastroplus, Matlab, Phoenix or other relevant softwareApply the models to new chemical entities for understanding tissuedistribution to inform drug-target coverage and safety margins,predicting absorption and PK, and evaluating the impact ofdrug-drug interactions Predict PK in special populations (e.g.hepatic or renal impairment patients, pediatrics, pregnantpopulation, diseased population, etc.) As required, develop novelPBPK models to answer mechanistic questions. Collaborate withmulti-functional project teams and functional group colleagues toidentify data requirements for model development, and strategiesfor model application and use. Education & Competencies (Technicaland Behavioral): PhD degree with 3 years relevant experience, Or MSwith 9 years relevant experience, or BS with 11 years relevantexperience in Pharmaceutical Sciences, Drug Metabolism andPharmacokinetics, Pharmacology or other relevant field Strongunderstanding of the concepts of, and prior experience in PBPKmodeling Strong training and understanding of the concepts of drugmetabolism and pharmacokinetics of diverse modalities (e.g. smallmolecules, biotherapeutics), biochemical aspects of drug metabolismenzymes and transporters, and various in vitro assays conducted toassess DDI potential Proficient in one or more of the followingmodeling and simulation software – Simcyp, Gastroplus, PK-Sim,Matlab and/or Simbiology, R, Phoenix, Berkley Madonna, ADAPT,Mathematica or other relevant software Track record of publicationand / or conference presentations Exceptional interpersonal, verbalcommunication and writing skills Good organizational and planningskills Provenrecord of accomplishmentof teamwork, adaptability,innovation,initiative,and integrity Strong quantitative, analyticaland problem-solving skills Global mindset to grow in a diverse workenvironment Takeda Compensation and Benefits Summary We understandcompensation is an important factor as you consider the next stepin your career. We are committed to equitable pay for allemployees, and we strive to be more transparent with our paypractices.

For Location:

Boston, MA U.S.

Base Salary Range:

$137,000.00 – $215,270.00 The estimated salary range reflects ananticipated range for this position. The actual base salary offeredmay depend on a variety of factors, including the qualifications ofthe individual applicant for the position, years of relevantexperience, specific and unique skills, level of educationattained, certifications or other professional licenses held, andthe location in which the applicant lives and/or from which theywill be performing the job.

The actual base salary offered will bein accordance with state or local minimum wage requirements for thejob location. U.S. based employees may be eligible for short-termand/or long-termincentives. U.S.based employees may be eligible toparticipate in medical, dental, vision insurance, a 401(k) plan andcompany match, short-term and long-term disability coverage, basiclife insurance, a tuition reimbursement program, paid volunteertime off, company holidays, and well-being benefits, among others.

U.S.based employees are also eligible to receive, per calendaryear, up to 80 hours of sick time, and new hires are eligible toaccrue up to 120 hours of paid vacation. EEO Statement Takeda isproud in its commitment to creating a diverse workforce andproviding equal employment opportunities to all employees andapplicants for employment without regard to race, color, religion,sex, sexual orientation, gender identity, gender expression,parental status, national origin, age, disability, citizenshipstatus, genetic information or characteristics, marital status,status as a Vietnam era veteran, special disabled veteran, or otherprotected veteran in accordance with applicable federal, state andlocal laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type RegularTime Type Full time Job Exempt Yes It is unlawful in Massachusettsto require or administer a lie detector test as a condition ofemployment or continued employment. An employer who violates thislaw shall be subject to criminal penalties and civil liability.